Advanced glycation end-product intermediaries and post-amadori inhibition

Abstract

The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.

1 . A compound of the general formula:  
     
       
         
         
             
             
         
       
       wherein R 1  is CH 2 NH 2 , CH 2 SH, COOH, CH 2 CH 2 NH 2 , CH 2 CH 2 SH, or CH 2 COOH;  
       R 2  and R 6  is H, OH, SH, NH 2 , C 1-6 alkyl, alkoxy or alkene;  
       R 4  and R 5  are H, C 1-6 alkyl, alkoxy or alkene;  
       Y is N or C, such that when Y is N R 3  is nothing, and when Y is C, R 3  is NO 2  or another electron withdrawing group, and salts thereof, wherein said compound is not pyridoxamine.  
     
   
   
       2 . A pharmaceutical composition comprising a compound of  claim 1 , or salt thereof in a suitable carrier.  
   
   
       3 . A method for inhibiting post-Amadori AGE formation comprising administering an effective post-Amadori AGE inhibiting amount of a compound of  claim 1 .  
   
   
       4 . A method for treating a patient with AGE related pathology comprising administering an effective therapeutic amount of a compound of  claim 1.