Non-woven fabric for biomedical application based on poly(ester-amide)s

Abstract

Electrospun biodegradable poly(ester-amide) fabric is especially suitable as a scaffold for tissue engineering and to incorporate drug for burn or wound healing treatment to accelerate healing, or to prevent tissue adhesion after surgery.

1 . A non-woven fabric consisting essentially of biodegradable electrospun poly(ester amide) for use for biomedical application, which is sterilizable and has an average fiber diameter ranging from 0.1 to 10.0 micrometer, a median pore size ranging from 0.1 to 100 micrometer, a surface area ranging from 10 to 300 m 2 /g, an average thickness ranging from 0.01 to 0.500 mm, a flexural rigidity ranging from 10 to 80 mg·cm, an average air permeability ranging from 10 to 100 ft 3 /min/ft 2 , an average water vapor transmission rate ranging from 200 to 500 g/m 2 /24 hr, a wettability contact angle ranging from 40 to 80 degrees, tensile stress property ranging from 0.01 to 0.10 kgf/mm 2 , tensile strain property ranging from 100 to 800%, Young's modulus ranging from 0.20 to 20.0 MPa and tensile toughness ranging from 0.50 to 3.0 MPa. 
     
     
         2 . The non-woven fabric of  claim 1  where the poly(ester-amide) is able to be solution electrospun. 
     
     
         3 . The non-woven fabric of  claim 2  where the poly(ester-amide) has a reduced viscosity ranging from 1.0 to 2.0 dL/g and is selected from the group consisting of one or more subunits A, and one or more subunits B, and combinations thereof, where the one or more subunits A have the structure 
       
         
           
           
               
               
           
         
       
       where R 1  is (C 2 -C 20 ) alkylene, and where R 3  is hydrogen, (C 1 -C 20 ) alkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 ) alkynyl or (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl; 
       and where the one or more subunits B have the structure 
       
         
           
           
               
               
           
         
       
       where R 2  is hydrogen or (C 6 -C 10 ) aryl (C 1 -C 6 ) alkyl and where R 5  is (C 2 -C 20 ) alkylene. 
     
     
         4 . The non-woven fabric of  claim 3  when seeded with NHEK cells show cell attachment and proliferation in a Calcein-AM assay. 
     
     
         5 . The non-woven fabric of  claim 4  where the polyester amide has the structure (I) where R 1  is (CH 2 ) 8 , R 3  is 
       
         
           
           
               
               
           
         
       
       and R 4  is C 4 -C 8  alkylene. 
     
     
         6 . The non-woven fabric of  claim 1  with drug or other agent that accelerates healing, matrixed therein. 
     
     
         7 . The non-woven fabric of  claim 1  where the pore size is tailored for the utility by variation of electrospinning conditions. 
     
     
         8 . A method for making the non-woven fabric of  claim 1  comprising solution electrospinning of poly(ester-amide) and varying thickness of the non-woven fabric and/or solution concentration and/or collection distance and/or voltage and/or fiber diameter to vary pore size.