US2007149475A1PendingUtilityA1

AUGMENTATION OF WOUND HEALING BY eIF-4E mRNA AND EGF mRNA

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Individually held — no corporate assignee on recordPriority: Oct 23, 2000Filed: Feb 28, 2007Published: Jun 28, 2007
Est. expiryOct 23, 2020(expired)· nominal 20-yr term from priority
Inventors:Mary MurrayScott Dulchavsky
C07K 14/485C07K 14/4705A61K 48/00
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Claims

Abstract

There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.

Claims

exact text as granted — not AI-modified
1 . A method for augmenting transient protein synthesis in a cell in vitro by administering mRNA encoding eIF4e directly to the cell, wherein administering said mRNA to said cell transiently increases protein synthesis in said cells.  
   
   
       2 . A non-therapeutic method for augmenting transient protein synthesis in a cell in vivo by administering mRNA encoding eIF4e directly to the cell, wherein administering said mRNA to said cell transiently increases protein synthesis in said cells.

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