US2007142338A1PendingUtilityA1

Tetracycline Derivatives and Methods of Use Thereof

59
Individually held — no corporate assignee on recordPriority: Oct 5, 2001Filed: Feb 11, 2007Published: Jun 21, 2007
Est. expiryOct 5, 2021(expired)· nominal 20-yr term from priority
Inventors:Joseph J. HlavkaRichard Ablin
A61K 31/65C07C 237/26C07C 2603/46A61P 31/04A61P 35/00
59
PatentIndex Score
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Claims

Abstract

A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives.

Claims

exact text as granted — not AI-modified
1 - 6 . (canceled)  
   
   
       7 . A method for treating breast cancer, melanoma, myeloma or prostate cancer, which comprises the step of: 
 administering to a subject in need of treatment for a cancer selected from the group consisting of breast cancer, melanoma, myeloma and prostate cancer an effective amount of a compound having the formula                          or a salt thereof.    
   
   
       8 . The method of  claim 7 , wherein the administering step comprises administering 9-amino-6-deoxy-5-hydroxytetracycline H 2 SO 4  to the subject.  
   
   
       9 . The method of  claim 7 , wherein the cancer is prostate cancer.  
   
   
       10 . The method of  claim 7 , wherein the cancer is breast cancer.  
   
   
       11 . The method of  claim 7 , wherein the cancer is melanoma.  
   
   
       12 . The method of  claim 7 , wherein the cancer is myeloma.  
   
   
       13 . A method for treating breast cancer, melanoma, myeloma or prostate cancer, which comprises the step of: 
 administering to a subject in need of treatment for a cancer selected from the group consisting of breast cancer, melanoma, myeloma and prostate cancer an effective amount of a compound having the formula                          or a salt thereof.    
   
   
       14 . The method of  claim 13 , wherein the administering step comprises administering 9-nitro-6-deoxy-5-hydroxytetracycline H 2 SO 4  to the subject.  
   
   
       15 . The method of  claim 13 , wherein the cancer is prostate cancer.  
   
   
       16 . The method of  claim 13 , wherein the cancer is breast cancer.  
   
   
       17 . The method of  claim 13 , wherein the cancer is melanoma.  
   
   
       18 . The method of  claim 13 , wherein the cancer is myeloma.

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