Use of insulin-like growth factor binding protein 3 (IGF-BP3) for inhibition of tumor growth

Abstract

A method of inhibiting proliferation of cells associated with a tumor in a subject which comprises administering to the subject a tumor cell proliferation amount of IGF-BP3, thereby inhibiting proliferation of the cells. An improved surgical method which comprises surgically resecting a tumor from a subject and administering to the subject an amount of a protein effective to inhibit metastasis of any tumor cells released in the subject's blood circulation during the surgical resection of the tumor.

1 . A method of inhibiting proliferation of cells associated with a tumor in a subject which comprises administering to the subject a tumor cell proliferation amount of IGF-BP3, thereby inhibiting proliferation of the cells.  
   
   
       2 . (canceled)  
   
   
       3 . The method of  claim 1 , wherein the tumor is associated with colon cancer, prostate cancer, breast cancer or lung cancer.  
   
   
       4 . An improved surgical method which comprises a surgical procedure on a subject and administering to the subject a prophylactically effective amount of IGF-BP3 to prevent proliferation of a tumor cell in the subject.  
   
   
       5 . The method of  claim 1 , wherein the subject is human.  
   
   
       6 . The method of  claim 1 , wherein the IGF-BP3 is recombinant IGF-BP3.  
   
   
       7 . The method of  claim 1 , wherein the administration is oral, intravenous or transdermal.  
   
   
       8 . The method of  claim 7  wherein the administration is intravenous.  
   
   
       9 . The method of  claim 4  wherein the surgical procedure is open abdominal surgery.  
   
   
       10 . The method of  claim 4  wherein the administration of IGF-BP3 is before start of the surgery.  
   
   
       11 . The method of  claim 4  wherein the administration of IGF-BP3 is concurrent with the surgery.  
   
   
       12 . The method of  claim 4  wherein the administration of IGF-BP3 is after the completion of the surgery.  
   
   
       13 . The method of  claim 4  wherein the surgical procedure is colorectomy or gastric bypass.  
   
   
       14 . An article of manufacture comprising packaging material, IGF-BP3, and instructions for use of the IGf-BP3 in a surgical procedure.  
   
   
       15 . A process of manufacturing the article of  claim 14  comprising combining the packaging material, the IGF-BP3, and the instructions so as to manufacture the article.  
   
   
       16 - 29 . (canceled)  
   
   
       30 . The method of  claim 4 , wherein the subject is human.  
   
   
       31 . The method of  claim 4 , wherein the IGF-BP3 is recombinant IGF-BP3.  
   
   
       32 . The method of  claim 4 , wherein the administration is oral, intravenous or transdermal.  
   
   
       33 . The method of  claim 31 , wherein the administration is intravenous.