Hemoglobin conjugates

Abstract

The invention provides a conjugate of hemoglobin and a nucleic acid cross-linking agent.

1 . A method of combating viral or bacterial infection, comprising: 
 (A) parenterally administering to a mammalian subject in need thereof an effective amount of a conjugate of hemoglobin and a nucleic acid cross-liking agent, and thereafter    (B) irradiating said subject.    
   
   
       2 . The method of  claim 1 , wherein in step (B), irradiation is applied internally.  
   
   
       3 . The method of  claim 2 , wherein prior to irradiation, luciferine is administered to said subject.  
   
   
       4 . The method of  claim 1 , wherein in step (B), irradiation is applied externally.  
   
   
       5 . The method of  claim 4 , wherein said irradiation is X-ray irradiation.  
   
   
       6 . The method of  claim 1 , wherein said viral infection in retroviral infection.  
   
   
       7 . The method of  claim 1 , wherein said nucleic acid cross-liking agent is a psoralen.  
   
   
       8 . The method of  claim 1 , wherein said nucleic acid cross-liking agent is selected from the group consisting of an isopsoralen, an acridine, a haloethylamine, a haloethylsulfide, an epoxide and an aziridine.  
   
   
       9 . The method of  claim 1 , wherein said nucleic acid cross-liking agent is 8-methoxy psoralen.  
   
   
       10 . The method of  claim 1 , wherein said nucleic acid cross-liking agent is meloxine.