Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene

Abstract

An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast cancer using an antibody specifically binding to the protein and a method of diagnosing breast cancer by determining whether the gene is expressed in a cell or not, are provided.

1 . A method of detecting the presence or absence of a breast cancer in a test sample, the method comprising: 
 contacting an isolated anti-BCRP antibody with a polypeptide sample isolated from breast tissue from a human,    wherein the anti-BCRP antibody specifically interacts with an isolated protein consisting of an amino acid sequence consisting of SEQ ID NO:4; and    detecting any anti-BCRP-antibody-protein complexes that are formed,    wherein an increase in anti-BCRP-antibody-protein complexes compared to a polypeptide sample isolated from normal breast cells indicates the presence of the breast cancer in the test sample.    
     
     
         2 . The method of  claim 1 , wherein the increase in anti-BCRP-antibody protein complexes compared to a polypeptide sample isolated from normal breast cells is about a 3% increase.