Putamen ovi

Abstract

The present invention pertains to a method for the preparation of putamen ovi, putamen ovi having a defined grain size distribution, and to the use of putamen ovi for the treatment of calcium deficiency and other disease conditions.

1 .- 26 . (canceled)  
     
     
         27 . A medicament for oral and/or local application as bone cement or in bone remodeling and implantation or for bone replacement with an osteoneogenesis-active potential for local bone formation, 
 the medicament comprising an active ingredient, the active ingredient being parts or all of the shell matrix of the palisade zone (MPM) of egg shells.    
     
     
         28 . The medicament of  claim 27 , wherein the active ingredient is formulated in the form of putamen ovi pulvis, in extracted form, by aqueous and/or organic and/or supercritical solvents, especially carbon dioxide, as powder, granules, capsule, tablet, coated tablet, pastille (lozenge) or paste.  
     
     
         29 . A method for obtaining an active ingredient from the shell matrix of the palisade zone (MPM) of egg shells, comprising the steps of: 
 a) dissolving mineral-containing glycoproteins (MGP1) as gels by autoclave treatment; and    b) isolating MGP1 from the exchanged aqueous phase by thermal, vacuum, and/or freeze drying.    
     
     
         30 . A method for obtaining an active ingredient from the shell matrix of the palisade zone (MPM) of egg shells, comprising the steps of: 
 a) dissolving mineral-containing glycoproteins (MGP2) as gels by means of aqueous and/or organic solvents or with supercritical fluids; and then    b) isolating MGP2 by thermal, vacuum, and/or freeze drying.    
     
     
         31 . A method for obtaining an active ingredient from the shell matrix of the palisade zone (MPM) of egg shells, comprising the steps of: 
 a) alkaline treatment of egg shell components of the central palisade zone, freed from inner and outer shell membranes and from the shell matrix of the palisade zone (POM) with boiling 1-5% NaOH solution;    b) filtering off the solution from the residual shell skeleton;    c) neutralizing; and    d) isolating MGP3 by vacuum and/or freeze drying.