Anaesthetic formulations

Abstract

Propofol Solubilised in aqueous micellar preparations of poloxamers is stable at low concentrations and that such preparations are effective administration forms for Propofol.

1 . An aqueous preparation of Propofol, wherein the Propofol is solubilised in a synergistic mix of poloxamers, the poloxamers being in a ratio from 2:8 to 8:2 w/w, and the synergistic mix being: P407 with P237, P407 with P188, or P338 with P188.  
   
   
       2 - 3 . (canceled)  
   
   
       4 . A preparation according to  claim 1 , wherein the total poloxamer concentration is above 0.5% and below 20% w/w.  
   
   
       5 . A preparation according to  claim 4 , wherein the poloxamer total concentration is between 6 and 14% w/v.  
   
   
       6 . A preparation according to  claim 5 , wherein the poloxamer total concentration is between 8 and 12% w/v.  
   
   
       7 . A preparation according to  claim 5 , wherein the poloxamer total concentration is about 10% w/w.  
   
   
       8 - 9 . (canceled)  
   
   
       10 . A preparation according to  claim 1 , comprising at least 1% w/w Propofol.  
   
   
       11 . A preparation according to  claim 1 , which does not demicellise at infinite dilution.  
   
   
       12 . A preparation according to  claim 1 , which is isotonic with blood.  
   
   
       13 . A preparation according to  claim 1 , consisting of Propofol, poloxamers and water.  
   
   
       14 . A preparation according to  claim 1 , consisting of Propofol, poloxamers and saline.  
   
   
       15 . A preparation according to  claim 1 , further comprising at least one constituent selected from the group consisting of sterlising agents, stabilising agents, and bacteriostats.  
   
   
       16 . A preparation according to  claim 1 , wherein the synergistic mix is P338 with P188.  
   
   
       17 . A preparation according to  claim 1 , wherein the synergistic mix is P407 with P188.  
   
   
       18 . A preparation according to  claim 1 , wherein the synergistic mix is P407 with P237.  
   
   
       19 . A preparation according to  claim 16 , wherein the total poloxamer concentration is above 0.5% and below 20% w/w.  
   
   
       20 . A preparation according to  claim 19 , wherein the poloxamer total concentration is about 10% w/w.  
   
   
       21 . A preparation according to  claim 17 , wherein the total poloxamer concentration is above 0.5% and below 20% w/w.  
   
   
       22 . A preparation according to  claim 21 , wherein the poloxamer total concentration is about 10% w/w.  
   
   
       23 . A preparation according to  claim 18 , wherein the total poloxamer concentration is above 0.5% and below 20% w/w.  
   
   
       24 . A preparation according to  claim 23 , wherein the poloxamer total concentration is about 10% w/w.  
   
   
       25 . An aqueous preparation of Propofol, wherein the Propofol is solubilised in a synergistic mixture of two poloxamers, the poloxamers being in ratio from 8:2 to 2:8 w/w, and the PPO sizes of the poloxamers differing by 500 Daltons or more.