Biogically non-degradable peptides, angiostensin converting enzyme inhibitor, drug and functional food

Abstract

The present invention provides novel in vivo indigestible peptides that are highly absorbable and hardly digestible in living organism when administered orally or through other route, and expected to effectively exhibit functions, such as hypotensive effect, in living organism, and ACE inhibitors prepared with the peptides, and medicine or functional food expected to effectively exhibit hypotensive effect in living organism. The in vivo indigestible peptides are dipeptides or tripeptides having Pro at the carboxyl terminals, selected from the group consisting of Ile-Pro, Glu-Pro, Arg-Pro, Gln-Pro, Met-Pro, and Ser-Pro-Pro.

1 . An in vivo indigestible peptide having Pro at a carboxyl terminal, selected from the group consisting of Ile-Pro, Glu-Pro, Arg-Pro, Gln-Pro, Met-Pro, and Ser-Pro-Pro.  
   
   
       2 . An angiotensin converting enzyme inhibitor comprising as an active ingredient in vivo indigestible peptides having Pro at carboxyl terminals, consisting at least one of Ile-Pro, Glu-Pro, Arg-Pro, Gln-Pro, Met-Pro, and Ser-Pro-Pro, or a salt thereof.  
   
   
       3 . Medicine having hypotensive effect comprising an angiotensin converting enzyme inhibitor of  claim 2 .  
   
   
       4 . Functional food having hypotensive effect comprising an angiotensin converting enzyme inhibitor of  claim 2.