Agents for sequestering aging factors and uses thereof

Abstract

Methods for the prevention or treatment of disorders and complications of disorders resulting from cell damage caused by an aging-related isoform of NADH oxidase (arNOX) are described. The agent for such inhibition comprises processed various Narcissus tazetta extracts, preferably IBR-DORMIN®, both alone and in combination with other inhibition agents, including ubiquinones like coenzyme Q. These agents bind arNOX and inhibit the ability of arNOX to generate reactive oxygen species, thereby decreasing the ability of arNOX to generate reactive oxygen species. Such agents, and their methods of administration, as extremely effective as part of anti-aging treatments.

1 . canceled  
     
     
         2 . A method for treating damaged skin, wherein said damage results from oxidative damage resulting from the generation of reactive oxygen species by arNOX, the method comprising: 
 administering to a patient, in an amount effective to treat said damage, a composition comprising a processed  Narcissus tazetta  product    
     
     
         3 . The method of  claim 2  wherein the composition comprises a  Narcissus tazetta  extract, a preservative and water.  
     
     
         4 . The method of  claim 2  wherein the total daily amount of processed  Narcissus tazetta  product administered is from about 1 to about 500 mg.  
     
     
         5 . The method of  claim 2  wherein the total daily amount of processed  Narcissus tazetta  product administered is from about 1 to about 100 mg.  
     
     
         6 . The method of  claim 2  wherein the composition further comprises a ubiquinone.  
     
     
         7 . The method of  claim 6 , wherein the ubiquinone is coenzyme Q 10 .  
     
     
         8 . The method of  claim 7  wherein coenzyme Q 10  is administered with a ubiquinone selected from a group consisting of coenzyme Q 5 , coenzyme Q 7 , coenzyme Q 8 , and coenzyme Q 9 .  
     
     
         9 . The method of  claim 2 , wherein the composition further an ingredient selected from a list comprising Shisandra Chinensis, Lonicera Japonica, Fagopyrum Cymosum, Methlyparaben, L-Carnosine, Propylparaben, Ethylparaben, L-Ergothioneine, Betulinic acid, Solanum Lycopersicum, Univestin, and Soliprin.  
     
     
         10 . The method of  claim 2  wherein the damage is a result of a primary disorder selected from a list comprising: old age, rheumatoid arthritis, cancer arthritis associated with age, and fatigue associated with age.  
     
     
         11 . The method of  claim 2  wherein the damage is a result of aged cells.  
     
     
         12 . The method of  claim 2 , wherein the damage is a result of a dermatological disorder selected from a list comprising: Acne Vulgaris, Adiposis Dolorosa, Albinism, Alopecia, alpha 1-Antitrypsin Deficiency, Atopic dermatitis, Baldness, Behcet's Syndrome, Birthmarks, Birt-Hogg-Dube Syndrome, Blister, Cafe-au-Lait Spots, Cellulitis, Cholesteatoma, Connective Tissue Diseases, Contractural Arachnodactyly, Cutis Laxa, Decubitus Ulcer, Dercum Disease, Dermatitis, Dermatitis Exfoliative, Dermatitis Herpetiformis, Ectodermal Dysplasia, Eczema, Ehlers-Danlos Syndrome, Epidermolysis Bullosa, Erysipelas, Erythema Multiforme, Exanthema Subitum, Furunculosis, Granuloma Annulare, Gustatory Sweating, Hailey-Hailey Disease, Hair Diseases, Hair Loss, Head Lice, Hidradenitis Suppurativa, Hirsutism, Hives, Hypohidrosis, Ichthyosis, Immersion Foot, Incontinentia Pigmenti, Keloid, Keratosis Actinic, Keratosis Follicularis, Keratosis Seborrheic, Leg Ulcer, Lentigo, Lichen Planus, Lichen Sclerosus et Atrophicus, Lipodystrophy, Lupus, Lupus Erythematosus Cutaneous, Lupus Erythematosus Systemic, Marfan Syndrome, Mastocytosis, Melanoma, Melanosis, Mixed Connective Tissue Disease, Nail Patella Syndrome, Nail Diseases, Nails Ingrown, Panniculitis, Parapsoriasis, Paronychia, Pemphigoid Bullous, Pemphigus, Pemphigus Benign Familial, Photosensitivity Disorders, Pigmentation Disorders, Pityriasis, Poison Ivy, Port-Wine Stain, Pruritus, Pseudoxanthoma Elasticum, Psoriasis, Pyoderma Gangrenosum, Rosacea, Scabies, Scleroderma, Scleroderma Systemic, Seborrheic Dermatitis, Shopping, Skin Cancer, Skin and Connective Tissue Diseases, Skin Diseases, Infectious Skin Diseases, Skin Ulcer, Stevens-Johnson Syndrome, Stickler Syndrome, Sweat Gland Diseases, Sweet's Syndrome, Swimmer's Itch, Tinea Versicolor, Urticaria, Vitiligo, Warts, Xanthomatosis, and Xeroderma Pigmentosum.  
     
     
         13 . The method of  claim 2  wherein the damage is selected from a list comprising wrinkles, fine lines, large pore size, acne, excessive sebum production, collagen damage, elastin damage and damaged fibroblasts.  
     
     
         14 - 45 . (canceled)