Targeted liposomal drug delivery system

Abstract

A metal targeting complex which associates with a charged liposomal structure is provided. The metal targeting complex provides the targetability of the liposomal construct to the desired receptor sites of a warm-blooded host for therapy or diagnostic use.

1 . A process for producing a target delivery molecule, which comprises: 
 (a) synthesizing a target molecule complex comprising (a′) a bridging agent selected from the group consisting of a transition element, an inner transition element, a neighbor element of said transition element and a mixture of any of the foregoing elements; and (b′) a complexing agent; provided that when said transition element is chromium a chromium target molecule complex is synthesized; and    (b) combining said target molecule into a liposomal matrix to form the target delivery molecule.    
     
     
         2 . The process as defined in  claim 1  wherein steps (a) and (b) are simultaneously carried out in situ.  
     
     
         3 . The process of  claim 1 , wherein said liposomal matrix comprises a charged liposomal structure.  
     
     
         4 . The process of  claim 1 , wherein said chromium target molecule complex is prepared by a method comprising 
 (a) combining an aqueous solution of N-(2,6-diisopropylphenylcarbamoylmethyl)iminodiacetic acid having an pH between 3.2 and 3.3 with an aqueous solution of a chromium compound having a pH between 4.0 and 4.4 to form a reaction solution;    (b) maintaining the reaction solution at a pH between 3.2 and 3.3 to form a complex solution; and    (c) incubating said complex solution to form said chromium complex.    
     
     
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         6 . The process of  claim 1  which further comprises the step of combining a pharmacological agent with the target delivery molecule to form a pharmacological delivery system.  
     
     
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         29 . A process for producing a hepatocyte directed vesicle comprising the steps of: 
 (a) reacting chromium with N-(2,6-diisoproplyphenylcarbamoylmethyl) iminodiacetic acid to form a chromium target molecule complex; and    (b) adding the chromium target molecule complex to a liposome to form the hepatocyte directed vesicle.    
     
     
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         31 . A process for producing a hepatocyte directed vesicle comprising the steps of: 
 (a) reacting a suitable metal selected from a transition metal other than chromium, an inner transition metal, a neighbor metal of said transition metal and a mixture of any of the foregoing metals with a suitable complexing agent to form a target molecule complex; and    (b) adding said complex to a liposome to form a hepatocyte directed vesicle.    
     
     
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