Catheters and methods of using catheters

Abstract

A catheter device and method, in which a first lumen coupled to a balloon, a second lumen coupled to the first lumen, the second lumen having a distal opening to dispense an oxygenated infusate, and a third lumen coupled to the second lumen and coupled to a second balloon. The second balloon restricts the flow of the oxygenated infusate, and the oxygenated infusate provides oxygen to tissue at a distal end of said catheter device.

1 - 5 . (canceled)  
   
   
       6 . A method of treating a body vessel, said method comprising: 
 inserting a catheter device comprising at least one lumen near a treatment site within said body vessel;    expanding a first inflatable member of said catheter device disposed upstream from said treatment site to obstruct blood flow;    infusing an oxygenated infusate through said catheter device and into said body vessel near said treatment site;    expanding a second inflatable member of said catheter device disposed downstream from said treatment site to reduce downstream flow rate where said oxygenated infusate can flow past said second inflatable member and perfuse portions of said body vessel downstream from said treatment site.    
   
   
       7 . The method of  claim 6 , wherein said oxygenated infusate further comprises a light activated bioagent.  
   
   
       8 . The method of  claim 6 , wherein said second inflatable member further comprises a balloon with variable diameter.  
   
   
       9 . The method of  claim 6 , wherein said catheter device further comprises a light diffuser disposed between said first inflatable member and said second inflatable member.  
   
   
       10 . The method of  claim 9 , wherein expanding said second inflatable member increases a resonance time for said light activated bioagent to infuse into said treatment site.  
   
   
       11 . A method of treating a body vessel, said method comprising: 
 inserting a catheter device including two inflatable members, a light diffuser and an infusion port into said body vessel near a treatment site;    expanding a first inflatable member proximal to said treatment site to occlude flow to said treatment site;    expanding a second inflatable member distal to said treatment site to reduce flow from said treatment site to portions of the vessel downstream from said second inflatable member;    infusing an oxygenated and light activated infusate through said infusion port about said treatment site; and    shining a light, capable of activating said oxygenated and light activated infusate, from said light diffuser about said treatment site.    
   
   
       12 . The method of claim  111  wherein said two inflatable members are of different constructions.  
   
   
       13 . The method of  claim 12  wherein said two inflatable members are of different shapes.  
   
   
       14 . The method of  claim 11  wherein said light diffuser and said infusion ports are disposed between said two inflatable members.  
   
   
       15 . The method of  claim 11  wherein said oxygenated and light activated infusate includes a drug to treat at least one of atherosclerosis, vessel occlusion and vessel inflammation.  
   
   
       16 . The method of  claim 15  wherein light at a particular frequency (or wavelength) and intensity is released from said light diffuser to activate light activated bioactive agent released from the infusion port.  
   
   
       17 . The method of  claim 15  wherein a light source for said light diffuser is at least one of a fiber optic assembly and a LED.  
   
   
       18 . The method of  claim 11  wherein the said second inflatable member is a balloon that has a variable diameter that forms perfusion paths along the balloon's outer surface.  
   
   
       19 . A method of treating a body vessel, said method comprising: 
 inserting a catheter device including two inflatable members and infusion ports into said body vessel near a treatment site;    expanding a first inflatable member disposed near a proximal end of the catheter device to occlude flow;    expanding a second inflatable member disposed near a distal end of the catheter device to partially impede a downstream flow; and    infusing an oxygenated and light activated infusate through said infusion ports and into said body vessel.    
   
   
       20 . The method of  claim 19  wherein the two inflatable members are of different constructions.  
   
   
       21 . The method of  claim 20  wherein the oxygenated and light activated further comprises a drug to treat at least one of atherosclerosis, vessel occlusion and vessel inflammation.  
   
   
       22 . The method of  claim 21  wherein said infusion ports and an additional light diffuser are both located between the two inflatable members.  
   
   
       23 . The method of  claim 22  wherein the light diffuser is capable of activating said light activated bioactive agent by shining a light from said light diffuser to said body vessel.  
   
   
       24 . The method of  claim 23  wherein light at a particular frequency (or wavelength) and intensity is released from said light diffuser to activate said infusate released from the infusion port.  
   
   
       25 . The method of  claim 24  wherein a light source for said light diffuser is at least one of a fiber optic assembly and a LED.  
   
   
       26 . A medical device, comprising: 
 a catheter with at least a proximal inflatable member and a distal inflatable member;    the proximal inflating member, after inflated, to occlude flow from upstream;    the distal inflating member, after inflated, to allow partial flow downstream; and    an oxygenated infusate infusion port displaced on the catheter device.    
   
   
       27 . The medical device of  claim 26  wherein the two inflatable members are of different constructions to control flow of blood or infusate.  
   
   
       28 . The medical device of  claim 27  wherein the distal inflatable member is a helical balloon.  
   
   
       29 . The medical device of  claim 26  wherein a light activated bioagent is mixed with the oxygenated infusate.  
   
   
       30 . The medical device of  claim 29  wherein a light diffuser is also displaced on the catheter device and a light source for the light diffuser is at least one of a fiber optic assembly and a LED.  
   
   
       31 . The medical device of  claim 30  wherein light at a particular frequency (or wavelength) and intensity is released from said light diffuser to activate said light activated bioagent.  
   
   
       32 . The medical device of  claim 30  wherein both the light diffuser and the oxygenated infusate infusion port are both displaced between the two inflating members.