Article of manufacture comprising aromatic amino acids isomers, analogs, or derivatives thereof to treat neurological disorders involving dysfunction of glutamatergic synaptic transmission

Abstract

Disclosed herein are articles of manufacture that comprise compositions comprising one or more aromatic amino acids, analogs or isomers thereof, and/or combinations thereof. The articles of manufacture are useful for treatment of neurological conditions related to or which can be affected by, modulation of glutamate receptor (GluR) activity.

1 . An article of manufacture useful in treating a neurological condition characterized by overactivation of an ionotropic glutamatergic receptor, said article containing a pharmaceutical composition consisting essentially of at least one aromatic amino acid, isomer, or analog thereof, wherein said at least one aromatic amino acid, isomer or analog thereof is D-tyrosine, D-tryptophan, or D-phenylalanine.  
   
   
       2 . An article of manufacture useful in treating a neurological condition characterized by overactivation of an ionotropic glutamatergic receptor, said article containing a pharmaceutical composition consisting essentially of at least one aromatic amino acid, isomer, or analog thereof, wherein said at least one aromatic acid, isomer or analog thereof is an admixture of D-tyrosine and D-tryptophan; D-tyrosine and D-phenylalanine; D-tryptophan and D-phenylalanine; or D-tyrosine, D-tryptophan, and D-phenylalanine.  
   
   
       3 . An article of manufacture useful in treating a neurological condition characterized by overactivation of an ionotropic glutamatergic receptor, said article containing a pharmaceutical composition consisting essentially of at least one aromatic amino acid, isomer, or analog thereof, wherein said at least one aromatic acid, isomer or analog thereof is an admixture of L-phenylalanine and D-phenylalanine.