US2007088068A1PendingUtilityA1

Benzo[F]Isoindole Derivatives With Affinity To The EP4 Receptor

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Individually held — no corporate assignee on recordPriority: Feb 9, 2001Filed: Nov 8, 2006Published: Apr 19, 2007
Est. expiryFeb 9, 2021(expired)· nominal 20-yr term from priority
Inventors:Miles Stuart CongreveGerard GiblinAndrew Mcmurtrie MasonNeil Derek MillerSusan RoomansAnn Louise Walker
A61P 35/00A61P 31/16A61P 9/10A61P 43/00A61P 31/12A61P 25/04A61P 29/00A61P 25/06A61P 29/02C07D 209/64A61P 1/00A61P 15/00A61P 19/02C07D 209/66A61P 19/06A61P 21/00A61P 19/04
55
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Claims

Abstract

A compound of formula (I) and processes for the preparation thereof.

Claims

exact text as granted — not AI-modified
1 .- 13 . (canceled)  
     
     
         14 . A process for the preparation of [4-(4,9-dipropoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid comprising reacting [4-(4,9-dipropoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetate with a reducing agent, and thereafter separating the isomers and deprotecting the compound so formed.  
     
     
         15 . A process according to claim  1  in which the reducing agent is zinc in acetic acid.  
     
     
         16 . A process according to claim  1  in which the reducing agent is sodium borohydride.  
     
     
         17 . A process according to claim  1  in which the reaction is performed under reflux.  
     
     
         18 . A process according to claim  1  in which the deprotection step comprises treatment with an aqueous base.  
     
     
         19 . A process according to claim  1  in which the deprotection step comprises treatment with aqueous potassium carbonate.

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