Method for screening PTPzeta activity promoter or inhibitor

Abstract

An object of the present invention is to provide a remedy for dysfunction of central monoamine pathway, a method for screening a PTPζ inhibitor or activator, which is useful as a remedy for gastric ulcer caused by Helicobacter pylori or pleiotrophin which is a heparin-binding secretory protein, and a non-human model animal being hyposensitive to a stimulant drug, VacA which is a toxin of Helicobacter pylori , or pleiotrophin by utilizing the physiological function of PTPζ. After administering a subject material to PTPζ knockout mice and wild-type mice, PTPζ activity in the PTPζ knockout mice and the wild-type mice is compared and evaluated to screen a PTPζ inhibitor or activator. Examples of the comparison and the evaluation of the PTPζ activity include the comparison and the evaluation of the function of central monoamine pathway such as changes in the level of central monoamine metabolism, sensitivity to a stimulant drug, the presence of dysfunction of mesolimbic dopamine pathway, level of acclimation to new circumstances, or stress-responsiveness, and the comparison and the evaluation of the level of binding to VacA, a toxin of Helicobacter pylori , or pleiotrophin.

1 - 21 . (canceled)  
     
     
         22 . A non-human model animal whose function of gene DNA that encodes proteoglycan-type receptor-type protein tyrosine phosphatase (PTPc) is deficient on its chromosome and which is hyposensitive to a central stimulant drug (an addictive drug).  
     
     
         23 . The non-human model animal according to  claim 22 , wherein the non-human animal is hyposensitive to a stimulant drug.  
     
     
         24 . The non-human model animal according to  claim 22 , wherein the non-human animal whose function of gene DNA that encodes PTPζ is deficient on its chromosome is purified by being backcrossed for 4 or more generations.  
     
     
         25 . The non-human model animal according to  claim 22 , wherein the non-human animal is a mouse.  
     
     
         26 . A non-human model animal whose function of gene DNA that encodes proteoglycan-type receptor-type protein tyrosine phosphatase (PTOC) is deficient on its chromosome and which is hyposensitive to VacA, a toxin of  Helicobacter pylori.    
     
     
         27 . A non-human model animal whose function of gene DNA that encodes proteoglycan-type receptor-type protein tyrosine phosphatase (PTOC) is deficient on its chromosome and which is hyposensitive to pleiotrophin, a heparin-binding secretory protein.  
     
     
         28 . The non-human model animal according to  claim 26 , wherein the non-human animal whose function of gene DNA that encodes PTPζ is deficient on its chromosome is purified by being backcrossed for 4 or more generations.  
     
     
         29 . The non-human model animal according to  claim 26 , wherein the non-human animal is a mouse.