Compositions and methods for treating hyperimmune response in the eye

Abstract

The present invention comprises and utilizes methods and compositions for treating hyperimmune reactions in the eye. Compositions comprising antibodies to gamma interferon alone and in combination with other drugs are described. Also disclosed in the invention are methods of applying a composition comprising interferon gamma antibodies topically to the eye to treat hyperimmune reactions, such as transplant rejection, uveitis, autoimmune diseases of the eye, and ocular disorders incidental to or connected with autoimmune diseases.

1 - 5 . (canceled)  
     
     
         6 . A method of treating uveitis in a patient, said method comprising administering to the patient a combination of an effective amount of an antibody to gamma interferon and an effective amount of a chemotherapeutic agent.  
     
     
         7 . The method of  claim 6 , wherein said antibody is selected from the group consisting of a polyclonal antibody, a monoclonal antibody, a humanized antibody, a synthetic antibody, a heavy chain antibody, a biologically active fragment of an antibody, wherein the biologically active fragment comprises an Fv fragment, an Fab fragment or an F(ab) 2  fragment, and combinations thereof.  
     
     
         8 . The method of  claim 6 , wherein said antibody is administered by the route selected from the group consisting of intramuscularly, intravenously, intradermally, cutaneously, ionophoretically, topically, and locally.  
     
     
         9 . The method of  claim 8 , wherein the antibody is administered topically.  
     
     
         10 . The method of  claim 9 , wherein the antibody is selected from the group consisting of a polyclonal antibody, a monoclonal antibody, a humanized antibody, a synthetic antibody, a heavy chain antibody, a biologically active fragment of an antibody, wherein the biologically active fragment comprises an Fv fragment, an Fab fragment or an F(ab) 2  fragment, and combinations thereof.  
     
     
         11 . The method of  claim 10 , wherein the heavy chain antibody is selected from the group consisting of a camelid antibody, a heavy chain disease antibody, and a variable heavy chain immunoglobulin.