AMPK activating agent

Abstract

The present invention relates to provision of AMPK activating agent, endurance enhancing agent, and antifatigue agent, which have rich history of use in foods, high safety, readily available, and high workability, a method of activating AMPK, and a method of preventing, treating and/or ameliorating a life-style-related disease. The present invention provides AMPK activating agent, endurance enhancing agent, and antifatigue agent, each of which contains nootkatone as an active agent. The present invention provides a method of activating AMPK characterized by administering nootkatone in an effective amount, and a method of preventing, treating and/or ameliorating a life-style-related disease characterized by administering nootkatone in an effective amount.

1 . An AMPK activating agent comprising nootkatone as an active ingredient.  
   
   
       2 . A lipid metabolism activating agent comprising nootkatone as an active ingredient.  
   
   
       3 . An antiobesity agent comprising nootkatone as an active ingredient.  
   
   
       4 . An antidiabetic agent comprising nootkatone as an active ingredient.  
   
   
       5 . An antiarteriosclerotic agent comprising nootkatone as an active ingredient.  
   
   
       6 . An antihyperlipidemic agent comprising nootkatone as an active ingredient.  
   
   
       7 . An exercise-substituting agent comprising nootkatone as an active ingredient.  
   
   
       8 . An endurance enhancing agent comprising nootkatone as an active ingredient.  
   
   
       9 . An antifatigue agent comprising nootkatone as an active ingredient.  
   
   
       10 . A method for activating AMPK comprising administering nootkatone in an effective amount.  
   
   
       11 . A method for preventing, treating and/or improving lifestyle-related disease, comprising administering nootkatone in an effective amount.  
   
   
       12 . The method according to  claim 11 , wherein the lifestyle-related disease is selected from obesity, hyperlipidemia, diabetes, and arteriosclerosis.  
   
   
       13 . A method for substituting exercise comprising administering nootkatone in an effective amount.  
   
   
       14 . A method for enhancing endurance and/or for removing fatigue comprising administering nootkatone in an effective amount.