US2007053998A1PendingUtilityA1
Butanol extract of Bidens pilosa
Est. expirySep 2, 2025(expired)· nominal 20-yr term from priority
C07H 15/10A61P 3/10A61K 36/28A61P 37/00
47
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Claims
Abstract
A compound of the formula: wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4. Also disclosed is use of the compound to inhibit Th1 differentiation, promote Th2 differentiation, and treat certain disorders.
Claims
exact text as granted — not AI-modified1 . An extract prepared by a method comprising:
stirring a pulverized Bidens pilosa plant in water to form a suspension, collecting an aqueous solution from the suspension, and extracting the aqueous solution with butanol to provide an extract.
2 . The extract of claim 1 , wherein the pulverized Bidens pilosa plant is stirred in boiling water.
3 . A method of inhibiting Th1 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 1 .
4 . A method of inhibiting Th1 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 2 .
5 . A method of promoting Th2 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 1 .
6 . A method of promoting Th2 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 2 .
7 . A method of inhibiting Th1 cell differentiation and promoting Th2 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 1 .
8 . A method of inhibiting Th1 cell differentiation and promoting Th2 cell differentiation, comprising administering to a subject in need thereof an effective amount of the extract of claim 2 .
9 . A compound of the following formula:
wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, or 4; n is 0; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4.
10 . The compound of claim 9 , wherein R 1 is methyl, R 2 is β-glucopyranose, R 3 is H, m is 4, o is 2, and p is 1.
11 . A method of inhibiting Th1 cell differentiation, comprising administering to a subject in need thereof a compound of the following formula:
wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4.
12 . The method of claim 11 , wherein R 1 is methyl, R 2 is β-glucopyranose, and R 3 is H.
13 . The method of claim 12 , wherein m is 4, n is 0, o is 2, and p is 1.
14 . The method of claim 12 , wherein m is 3, n is 1, o is 2, and p is 2.
15 . The method of claim 12 , wherein m is 3, n is 1, o is 2, and p is 1.
16 . A method of promoting Th2 cell differentiation, comprising administering to a subject in need thereof a compound of the following formula:
wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4.
17 . The method of claim 16 , wherein R 1 is methyl, R 2 is β-glucopyranose, and R 3 is H.
18 . The method of claim 17 , wherein m is 4, n is 0, o is 2, and p is 1.
19 . The method of claim 17 , wherein m is 3, n is 1, o is 2, and p is 2.
20 . The method of claim 17 , wherein m is 3, n is 1, o is 2, and p is 1.
21 . A method of inhibiting Th1 cell differentiation and promoting Th2 cell differentiation, comprising administering to a subject in need thereof a compound of the following formula:
wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4.
22 . The method of claim 21 , wherein R 1 is methyl, R 2 is β-glucopyranose, and R 3 is H.
23 . The method of claim 22 , wherein m is 4, n is 0, o is 2, and p is 1.
24 . The method of claim 22 , wherein m is 3, n is 1, o is 2, and p is 2.
25 . The method of claim 22 , wherein m is 3, n is 1, o is 2, and p is 1.
26 . A method of treating a Th1-mediated disorder, comprising administering to a subject in need thereof an effective amount of the extract of claim 1 , wherein the Th1-mediated disorder is non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis.
27 The method of claim 26 , wherein the Th1-mediated disorder is non-obese diabetes.
28 . A method of treating a Th1-mediated disorder, comprising administering to a subject in need thereof a compound of the following formula:
wherein R 1 is H, alkyl, aryl, or cyclyl; R 2 is pyranose; R 3 is H or alkyl; m is 2, 3, 4, 5, or 6; n is 0, 1, 2, or 3; o is 0, 1, 2, 3, 4; and p is 1, 2, 3, or 4; the Th1-mediated disorder being non-obese diabetes, Crohn's colitis, autoimmune hemolytic anemia, rheumatoid arthritis, autoimmune encephalitis, multiple sclerosis, or autoimmune myocarditis.
29 . The method of claim 28 , wherein R 1 is methyl, R 2 is β-glucopyranose, and R 3 is H.
30 . The method of claim 29 , wherein m is 4, n is 0, o is 2, and p is 1.
31 . The method of claim 29 , wherein m is 3, n is 1, o is 2, and p is 2.
32 . The method of claim 29 , wherein m is 3, n is 1, o is 2, and p is 1.
33 . The method of claim 28 , wherein the Th1-mediated disorder is non-obese diabetes.Join the waitlist — get patent alerts
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