Process for co-spray drying liquid herbal extracts with dry silicified MCC

Abstract

A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.

1 . A process for preparing dry extracts from a liquid extract and at least one additional substance by a spray-drying process, characterized in that said at least one additional substance is added to the spray-drying process in a dry form during the spray-drying processes.  
   
   
       2 . The process according to  claim 1 , characterized in that said liquid extract is the extract of a medicinal plant.  
   
   
       3 . The process according to  claim 1 , characterized in that said at least one additional substance is a galenic auxiliary agent.  
   
   
       4 . The process according to  claim 3 , characterized in that said auxiliary agent is selected from the group consisting of lactose, maltodextrin, dextrin, dry glucose, starch, microcrystalline cellulose, Povidone®, polyethylene glycol, calcium phosphate, magnesium stearate, precipitated silicic acid, precipitated silica, highly dispersed silica, sorbitol, mannitol, and mixtures thereof.  
   
   
       5 . The process according to  claim 1 , characterized in that the particle size of said at least one additional substance is within a range of from 1 to 500 μm.  
   
   
       6 . A process of creating agglomerated particles containing an herbal extract comprising combining a wetted herbal extract with dry silicified microcrystalline cellulose using a spray dryer to form agglomerated particles.  
   
   
       7 . The process of  claim 6 , wherein the herbal extract is hygroscopic.  
   
   
       8 . A process of creating agglomerated particles containing an herbal extract comprising: 
 a) providing an herbal extract suitable for spray drying; and    b) combining the herbal extract with dry silicified microcrystalline cellulose in a    dryer to form agglomerated particles.    
   
   
       9 . The process of  claim 8 , wherein the herbal extract is hygroscopic.  
   
   
       10 . The process of  claim 8 , wherein the silicified microcrystalline cellulose is formed into a slurry before spray drying.  
   
   
       11 . The process of  claim 8 , wherein the silicified microcrystalline cellulose is combined with the active agent prior to spray drying.  
   
   
       12 . The process of  claim 1 , wherein the auxiliary agent is silicified microcrystalline cellulose.  
   
   
       13 . A method of manufacturing agglomerated particles containing a herbal extract comprising combining a wetted herbal extract with dry silicified microcrystalline cellulose  
     in a dryer to form agglomerated particles.  
   
   
       14 . The method of  claim 13 , wherein said dryer is a spray dryer.  
   
   
       15 . The method of  claim 13 , wherein said silicified microcrystalline cellulose comprises excipient particles comprising a particulate agglomerate of microcrystalline cellulose coprocessed with from about 0.1% to about 20% by weight silicon dioxide, the microcrystalline cellulose and silicon dioxide being in intimate association with each other and said silicon dioxide being integrated with or partially coating said microcrystalline cellulose, said silicon dioxide portion of said agglomerate being derived from a silicon dioxide having an average primary particle size from about 1 nm to about 100 μm.  
   
   
       16 . The method of  claim 13 , wherein said silicon dioxide is derived from a silicon dioxide having an average primary particle size from about 5 nm to about 40 μm.  
   
   
       17 . The method of  claim 13 , wherein said silicon dioxide is derived from colloidal silicon dioxide.  
   
   
       18 . The method of  claim 13 , wherein said silicon dioxide is from about 0.5% to about 10% by weight, based on the weight of said microcrystalline cellulose.  
   
   
       19 . The method of  claim 13 , wherein said excipient particles have an average particle size of from about 10 μm to about 500 μm.  
   
   
       20 . The method of  claim 13 , wherein said silicon dioxide is derived from a silicon dioxide having a surface area from about 175 m 2 /g to about 350 m 2 /g.  
   
   
       21 . The method of  claim 19 , wherein said excipient has a bulk density from about 0.35 g/ml to about 0.55 g/ml.  
   
   
       22 . The process of  claim 6 , wherein the herbal extract is selected from the group consisting of Alfalfa Leaf, Alfalfa Juice, Aloee-emodin, Andrographolide, Angelica Root, Astragalus Root, Bilberry, Black Cohosh Root, Black Walnut Leaf, Blue Cohosh Root, Burdock Root, Cascara Bark, Cats Claw Bark, Catnip Leaf, Cayenne, Chamomile Flowers, Chaste Tree Berries, Chickweed, Chinese Red Sage Root, Cranberry, Chrysophanol, Comfrey Leaf, Cramp Bark, Damiana Leaf, Dandelion Root CO, Devil's Claw Root, Diosgenin, Dong Quai Root, Dong Quai; Echinacea, Echinacea Angustifolia Root, Echinacea Purpurea Herb Root and Echinacea Angust./Purpurea Blend CO, Echinacea Angust./Goldenseal Blend, Eleuthero (Siberian) Ginseng Root, Emodin, Eyebright Herb, Fenugreek, Feverfew Herb CO, Of-Ti Root, Of-Ti, Garcinia Cambogia, Gentian Root, Ginger, Ginko Biloba Ginger Root, Ginseng, Ginko Leaf, Ginseng Root, Goldenseal Root, Gotu Kola Herb, Grape Seed, Grape Skin, Green Tea, Green Tea, Decaf, Guarana Seeds, Gynostemma Pentaphyllum, Hawthorn Berries, Hawthorn Leaf, Hesperdin, Hops Flowers, Horehound Herb, Horse Chestnut, Horsetail, Hyssop Leaf, Huperzine A, Juniper Berries, Kava Kava Root, Kola Nut, Lavender Flowers, Lemon Balm, Licorice Root, Lobelia Herb, Lomatium, Marshmallow Root, Milk Thistle Seed, Milk Thistle, Mullein Leaf, Myrrh, Naringin, Neohesperidin, Nettle Leaf, Olive Leaf, Oregon Grape Root, Papain, Parsley Leaf & Root, Passion Flower, Pau D'Arco Bark, Pennyroyal, Peppermint Leaf, Physcion, Polystictus Versicolor Mushroom, Quercetin, Red Clover Blossoms, Red Clover, Red Raspberry Leaf, Red Yeast Rice, Reishi Mushrooms, Rhein, Rhubarb Root, Rosemary Leaf, Rutin, Sarsaparilla Root, Saw Palmetto, Saw Palmetto Berry, Schisandra Berries, Schisandra, Scullcap Herb, Shavegrass Herb, Sheep Sorrel, Shepard's Purse Herb, Shitake Mushroom, Slippery Elm Bark, Sown Orange, Soybean, Stevia Rebaudiana, St. John's Wort, Tetrandrine, Turmeric, Usnea Lichen, Uva Ursi, Uva Ursi Leaf, Valerian Root, White Willow Bark, Wild Yam Root, Yellow Dock Root, Yohimbe Bark, Yucca Root, and combinations thereof.