US2007053901A1PendingUtilityA1

Optimized Fc variants and methods for their generation

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Assignee: XENCOR INCPriority: Mar 1, 2002Filed: Jul 27, 2006Published: Mar 8, 2007
Est. expiryMar 1, 2022(expired)· nominal 20-yr term from priority
Inventors:Gregory Alan LazarArthur J. ChirinoWei DangJohn DesjarlaisStephen K. DobersteinRobert HayesSher Bahadur KarkiOmid Vafa
C07K 16/3015C07K 2317/732C07K 2317/92C07K 16/2887C07K 2317/77C07K 16/32C07K 2317/71C07K 16/2893C07K 16/30A61K 2039/505C07K 16/283C07K 16/2896C07K 16/00C07K 16/22C07K 2317/734C07K 2317/34C07K 16/2863C07K 2317/72
59
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Claims

Abstract

The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Claims

exact text as granted — not AI-modified
1 . A variant protein comprising an Fc variant of a wild-type Fc polypeptide, said Fc variant comprising at least one amino acid modification in the Fc region of said wild-type Fc polypeptide, wherein said variant protein exhibits altered binding to an Fc□R as compared to the wild-type Fc polypeptide.  
     
     
         2 .- 37 . (canceled)

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