US2007032426A1PendingUtilityA1

Therapeutic and diagnostic methods for ulcerative colitis and associated disorders

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Individually held — no corporate assignee on recordPriority: Feb 8, 2000Filed: Aug 7, 2006Published: Feb 8, 2007
Est. expiryFeb 8, 2020(expired)· nominal 20-yr term from priority
Inventors:Kiron M. Das
A61P 35/00A61P 27/02C07K 16/18A61K 31/23A61P 1/00A61K 31/351A61P 19/02A61K 31/131A61K 49/0004A61P 1/16A61P 19/08A61P 1/04A61P 19/10A01K 2227/40A61K 31/00A61P 17/00A61P 17/14A61P 17/06A61K 38/1709
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Claims

Abstract

This invention relates to the field of therapy and diagnostic methods for ulcerative colitis. Specifically, the method comprises administering a compound or recombinant protein that inhibits interaction between CEP and human tropomyosin. Also included in the invention are methods to screen for drugs useful in treating ulcerative colitis and diagnostic methods for detecting diseases associated with an autoanticen response to hTM in affected tissue.

Claims

exact text as granted — not AI-modified
1 . A method for treating or preventing ulcerative colitis and other associated diseases in target cells, comprising administering a compound to the target cells, wherein said compound inhibits interaction between CEP and hTM.  
   
   
       2 . A method for inhibiting the externalization of hTM5 comprising contacting a cell with an agent which blocks the secretion of a hTM5 and CEP complex thereby inhibiting the externalization of hTM5.

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