Bioadhesive gel based on hydroxyethycellulose

Abstract

Disclosed are compositions in the form of a bioadhesive gel that adheres to the mucous membranes, in particular the vaginal mucosa, for the application of active ingredients and/or principles, comprising hydroxyethylcellulose as the only gelling agent.

1 . A composition in the form of an aqueous bioadhesive gel adapted for the delivery of at least one of active ingredients and principles, said composition comprising hydroxyethylcellulose as the only gelling agent and a bioadhesive agent, glycerol and diethylene glycol monoethyl ether, together with at least one surfactant, preservative and acidifier.  
   
   
       2 . The composition as claimed in  claim 1 , comprising 1 to 5% by weight of hydroxyethylcellulose, 25 to 90% by weight of water, 5 to 25% by weight of glycerol, 5 to 50% by weight of diethylene glycol monoethyl ether, 0.01 to 10% by weight of surfactant, 0.05 to 1% by weight of preservative, and 0.01 to 1% weight of acidifier.  
   
   
       3 . The composition as claimed in  claim 1  further comprising, as an active constituent, at least one selected from the group consisting of antifungals, antiseptics, antimicrobials, antibiotics, analgesics, local anaesthetics, antihistamines, anti-inflammatory agents, contraceptives, hormones, and combinations thereof.  
   
   
       4 . The composition as claimed in  claim 3 , wherein the active constituent is at least one selected from the group consisting of econazole, miconazole, fluconazole, cyclopiroxolamine, nifuratel, nystatin, chlorhexidine, ibuprofen, ketoprofen, naproxen, benzydamine, benzalkonium chloride or other quaternary ammonium antiseptics, and nonxynol-9.  
   
   
       5 - 6 . (canceled)