US2007031420A1PendingUtilityA1

MASP-2, a complement-fixing enzyme, and uses for it

63
Individually held — no corporate assignee on recordPriority: Apr 3, 1997Filed: Jun 29, 2006Published: Feb 8, 2007
Est. expiryApr 3, 2017(expired)· nominal 20-yr term from priority
Inventors:Jens Chr. JenseniusSteffen Thiel
C12Q 1/37C07K 16/40C07K 2317/76C07K 2317/23C07K 2317/11A61K 38/482
63
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Claims

Abstract

The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway.

Claims

exact text as granted — not AI-modified
1 . A method of treatment comprising administration of a pharmaceutically effective amount of an inhibitor of MASP-2 to an individual suffering from excessive activity of the MBLectin pathway.  
     
     
         2 . The method according to  claim 1 , wherein said inhibitor inhibits the complement activating activity of MASP-2.  
     
     
         3 . The method according to  claim 1 , wherein said inhibitor inhibits the serine protease activity of MASP-2.  
     
     
         4 . The method according to  claim 1 , wherein said inhibitor prevents the formation of a functional complex of MASP-2 and MBL.  
     
     
         5 . The method according to  claim 1 , wherein said inhibitor is a MASP-2 antibody.  
     
     
         6 . The method according to  claim 1 , wherein said inhibitor is administered to regulate inflammation caused by activity of the MBLectin pathway.  
     
     
         7 . The method according to  claim 1 , wherein said excessive activity of the MBLectin pathway is caused by excessive MASP-2 activity.

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