Personal care compositions

Abstract

Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.

1 . A personal care composition comprising: 
 (a) a dipeptide based molecule, wherein the C terminal amino acid of said dipeptide based molecule is threonine; and    (b) a dermatologically or orally acceptable carrier or injectible liquid.    
     
     
         2 . The personal care composition of  claim 1 , wherein the N terminal amino acid of said dipeptide based molecule is a basic amino acid.  
     
     
         3 . The personal care composition of  claim 2 , wherein the N terminal amino acid of said dipeptide based molecule is selected from the group consisting of lysine, arginine, and histidine.  
     
     
         4 . The personal care composition of  claim 3 , wherein the N terminal amino acid of said dipeptide based molecule is lysine.  
     
     
         5 . The personal care composition of  claim 1 , wherein said amino acid comprises an N acyl derivative of said dipeptide based molecule.  
     
     
         6 . The personal care composition of  claim 5 , wherein said N acyl derivative is an ester.  
     
     
         7 . The personal care composition of  claim 6 , wherein said C terminal amino acid is a nitrogen containing derivative.  
     
     
         8 . The personal care composition according to  claim 1 , wherein said dipeptide is a derivative selected from the group consisting of His-Thr, Arg-Thr, Lys-Thr, Alk-His-Thr, Alk-Arg-Thr, Alk-Lys-Thr, His-Thr-OAlk, Arg-Thr-OAlk, Lys-Thr-OAlk, His-Thr-NR 1 R 2 , Arg-Thr-NR 1 R 2 , Lys-Thr-NR 1 R 2 , Alk-His-Thr-OAlk, Alk-Lys-Thr-NR 1 R 2 , Alk-Lys-Thr-OAlk, and combinations thereof.  
     
     
         9 . A personal care composition comprising: 
 (a) a dipeptide, wherein said dipeptide has the following structure:                          wherein        A=NH 3   + (CH 2 ) 4 —, NH 2   + =C(NH 2 )NH—(CH 2 ) 3 — or                          B=—NH 2 , —NH 3   + , —NH—D,    D=an acyl group of 2-22 carbon atoms in length, or biotinyl group and    E=—O—Alk, —NR 1 R 2 , —H, —O − , or —OH,    wherein Alk is an alkyl group of 1-24 carbons in length, and R 1  and R 2  are independently H or an alkyl group of 1-12 carbons in length; and    (b) a dermatologically or orally acceptable carrier or injectible liquid.    
     
     
         10 . The composition of  claim 9  wherein B is —NH—D.  
     
     
         11 . The composition of  claim 9  wherein B is H.  
     
     
         12 . The composition of any one of claims  9 ,  10  or  11 , wherein A is NH 3   + (CH 2 ) 4 —.  
     
     
         13 . The composition of  claim 9  wherein E is —O − , or —OH.  
     
     
         14 . The composition of  claim 10  wherein E is —O − , or —OH.  
     
     
         15 . The composition of  claim 11  wherein E is —O − , or —OH.  
     
     
         16 . The composition of  claim 12  wherein E is —O − , or —OH.  
     
     
         17 . A personal care composition, wherein said personal care composition comprises: 
 (a) a dipeptide based molecule, wherein said dipeptide based molecule comprises: His-Thr, Arg-Thr, Lys-Thr, Alk-His-Thr, Alk-Arg-Thr, Alk-Lys-Thr, His-Thr-OAlk, Arg-Thr-OAlk, Lys-Thr-OAlk, His-Thr-NR 1 R 2 , Arg-Thr-NR 1 R 2 , Lys-Thr-NR 1 R 2 , Alk-His-Thr-OAlk, Alk-Lys-Thr-NR 1 R 2 , or Alk-Lys-Thr-OAlk wherein Alk refers to an N-acyl derivative, OAlk refers to an alkyl group attached to the C terminal carbonyl of said Thr, and wherein R 1  and R 2  are independently H or an alkyl group of 1-12 carbons in length; and    (b) a dermatologically or orally acceptable carrier or injectible liquid.    
     
     
         18 . A personal care composition, wherein said personal care composition comprises: 
 (a) a dipeptide based molecule, where said dipeptide based molecule consists essentially of: His-Thr, Arg-Thr, Lys-Thr, Alk-His-Thr, Alk-Arg-Thr, Alk-Lys-Thr, His-Thr-OAlk, Arg-Thr-OAlk, Lys-Thr-OAlk, His-Thr-NR 1 R 2 , Arg-Thr-NR 1 R 2 , Lys-Thr-NR 1 R 2 , Alk-His-Thr-OAlk, Alk-Lys-Thr-NR 1 R 2 , or Alk-Lys-Thr-OAlk wherein Alk refers to an N-acyl derivative or biotinyl group, OAlk refers to an alkyl group attached to the C terminal carbonyl of said Thr, and wherein R 1  and R 2  are independently H or an alkyl group of 1-12 carbons in length; and    (b) a dermatologically or orally acceptable carrier or injectible liquid.    
     
     
         19 . The composition of  claim 1 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide in an amount effective to treat mammalian keratinous tissue condition.  
     
     
         20 . The composition of  claim 9 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide in an amount effective to treat mammalian keratinous tissue condition.  
     
     
         21 . The composition of  claim 17 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide in an amount effective to treat mammalian keratinous tissue condition.  
     
     
         22 . The composition of  claim 18 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide in an amount effective to treat mammalian keratinous tissue condition.  
     
     
         23 . The composition of  claim 1 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide at a concentration of from about 0.000001% to about 10%, by weight based on the weight of said composition.  
     
     
         24 . The composition of  claim 9 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide at a concentration of from about 0.000001% to about 10%, by weight based on the weight of said composition.  
     
     
         25 . The composition of  claim 17 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide at a concentration of from about 0.000001% to about 10%, by weight based on the weight of said composition.  
     
     
         26 . The composition of  claim 18 , wherein said composition comprises a dermatologically acceptable carrier, and wherein said composition comprises said dipeptide at a concentration of from about 0.000001% to about 10%, by weight based on the weight of said composition.