Automated liquid manufacturing system

Abstract

A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions to the diluent stream sufficiently in advance of one another so that adverse chemical reactions do not occur. The method also adjusts a pH level of the diluent prior to adding any of the concentrate solutions to the diluent.

1 . A method for continuously mixing aqueous solutions, comprising the steps of: 
 providing a flow controlled turbulent diluent stream;    adding a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream in such a manner that none of the ingredients of the concentrate solutions adversely chemically react with each other; and    thereby forming a diluted mixture of said concentrate solutions.    
     
     
         2 - 12 . (canceled)  
     
     
         13 . An apparatus for continuously mixing aqueous solutions comprising: 
 a static mixing chamber, having a an upstream end and a downstream end, for creating a turbulent diluent stream from a diluent introduced from the upstream end of said static mixing chamber; and    a plurality of injection ports, incorporated into said static mixing chamber, for introducing a plurality of chemically incompatible concentrate solutions to said turbulent diluent stream in such a manner that none of the ingredients of the concentrate solutions adversely chemically react with each other to thereby form a diluted mixture of said concentrate solutions at the downstream end of said static mixing chamber.    
     
     
         14 - 65 . (canceled)  
     
     
         66 . A computer program product for use with a computer system, said computer program product comprising: 
 a computer usable medium having computer readable program code means embodied in said medium for causing the computer system to control the continuous preparation of medium from concentrated solutions, said computer readable program code means comprising:    computer readable program code means for enabling the computer system to control a flow of a diluent into a static mixing chambers, wherein said static mixing chamber provides a turbulent diluent stream in accordance with said flow;    computer readable program code means for enabling the computer system to control a flow of a plurality of chemically incompatible concentrate solutions into said static mixing chamber, wherein said plurality of concentrate solutions admix with said turbulent diluent stream in such a manner that none of the ingredients of the concentrate solutions adversely chemically react with each other to thereby form a diluted mixture of said concentrate solutions.    
     
     
         67 - 81 . (canceled)  
     
     
         82 . A medium product produced by the method of  claim 1 .  
     
     
         83 . The medium product of  claim 82 , wherein said medium product is a 1× cell culture medium.  
     
     
         84 . The medium product of  claim 82 , wherein said medium product is a concentrated cell culture medium.  
     
     
         85 . The medium product of  claim 82 , wherein said medium product is a buffered salt solution.  
     
     
         86 . The medium product of  claim 82 , wherein said medium product is a cell culture medium that is between 1×-10×.  
     
     
         87 . The product of  claim 82 , wherein said medium product is a 10× cell culture medium.  
     
     
         88 . The medium product of  claim 82 , wherein said medium product is a salt solution.