US2007004659A1PendingUtilityA1

Method for preventing or delaying the onset of diabetes

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Individually held — no corporate assignee on recordPriority: Apr 17, 2000Filed: Dec 21, 2005Published: Jan 4, 2007
Est. expiryApr 17, 2020(expired)· nominal 20-yr term from priority
Inventors:Alan P. EscherJingxue Liu
A61K 48/00A61K 31/70A61K 38/51A61P 3/10C12Y 113/12005C12Y 401/01015A61K 38/44
50
PatentIndex Score
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Cited by
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Claims

Abstract

A method for preventing, delaying the onset of or treating diabetes in a patient comprising selecting a patient who is susceptible to developing diabetes, who is developing diabetes or who is diabetic and administering to the patient one or more than one dose of a pharmaceutical agent comprising a polynucleotide encoding a secreted exogenous protein, such as a secreted luciferase or a secreted form of human glutamic acid decarboxylase.

Claims

exact text as granted — not AI-modified
1 . A method for preventing or delaying the onset of diabetes in a patient comprising: 
 a) selecting a patient who is susceptible to developing diabetes, who is developing diabetes or who is diabetic;    b) administering to the patient one or more than one dose of a pharmaceutical agent comprising a polynucleotide encoding a secreted glutamic acid decarboxylase.    
     
     
         2 . The method of  claim 1 , where selecting the patient comprises identifying in the patient the presence of anti-insulin or anti-GAD autoantibodies or both anti-insulin and anti-GAD autoantibodies.  
     
     
         3 . The method of  claim 1 , where selecting the patient comprises identifying in the patient the presence of increasing hyperglycemia.  
     
     
         4 . The method of  claim 1 , where selecting the patient comprises identifying in the patient the presence of glycosuria.  
     
     
         5 . The method of  claim 1 , where selecting the patient comprises identifying in the patient the presence of a genetic predisposition to diabetes.  
     
     
         6 . The method of  claim 1 , where the one or more than one dose is a plurality of doses.  
     
     
         7 . The method of  claim 1 , where administering to the patient one or more than one dose comprises injecting the patient intramuscularly with the one or more than one dose.  
     
     
         8 . The method of  claim 1 , where the glutamic acid decarboxylase comprises a sequence according to SEQ ID NO:3.  
     
     
         9 . The method of  claim 1 , further comprising, after administering, monitoring the patient for the development diabetes.

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