Osteogenic implants for soft tissue

Abstract

An osteogenic implant includes a degradation agent in solid form and an osteogenerative agent in solid form. The osteogenic implant is configured to release the degradation agent prior to releasing the osteogenerative agent.

1 . An osteogenic implant comprising: 
 a degradation agent in solid form; and    an osteogenerative agent in solid form;    wherein the osteogenic implant is configured to release the degradation agent prior to releasing the osteogenerative agent.    
   
   
       2 . The osteogenic implant of  claim 1 , wherein the osteogenerative agent is an osteoconductive agent.  
   
   
       3 . The osteogenic implant of  claim 1 , wherein the osteogenerative agent is an osteoinductive agent.  
   
   
       4 . (canceled)  
   
   
       5 . The osteogenic implant of  claim 1 , wherein the degradation agent includes a nucleolytic agent.  
   
   
       6 .- 7 . (canceled)  
   
   
       8 . The osteogenic implant of  claim 1 , wherein the degradation agent is included in a microsphere.  
   
   
       9 . The osteogenic implant of  claim 8 , wherein the microsphere is included in a solution.  
   
   
       10 . (canceled)  
   
   
       11 . The osteogenic implant of  claim 1 , wherein the degradation agent is included in an outer layer of the osteogenic implant surrounding a core layer including the osteogenerative agent.  
   
   
       12 . The osteogenic implant of  claim 1 , further including an outer layer having an opening, wherein the degradation agent is included in a first region within the outer layer and the osteogenerative agent is included in a second region within the outer layer.  
   
   
       13 . The osteogenic implant of  claim 12 , wherein the first region is closer to the opening than the second region.  
   
   
       14 . The osteogenic implant of  claim 1 , wherein the degradation agent is included in a polymeric matrix.  
   
   
       15 .- 16 . (canceled)  
   
   
       17 . The osteogenic implant of  claim 1 , wherein the osteogenerative agent is included in a polymer matrix.  
   
   
       18 .- 19 . (canceled)  
   
   
       20 . The osteogenic implant of  claim 1 , further comprising an anesthetic agent or an analgesic agent.  
   
   
       21 . The osteogenic implant of  claim 20 , wherein the osteogenic implant is configured to release at least a portion of the anesthetic agent or the analgesic agent in conjunction with the degradation agent.  
   
   
       22 .- 24 . (canceled)  
   
   
       25 . The osteogenic implant of  claim 1 , wherein the osteogenic implant includes an elongated form and a tapered end.  
   
   
       26 . An osteogenic implant comprising: 
 a first polymer matrix including a degradation agent; and    a second polymer matrix including an osteogenerative agent;    wherein the first polymer matrix is configured to release at least a portion of the degradation agent prior to time at which the second polymer matrix is configured to release the osteogenerative agent.    
   
   
       27 . The osteogenic implant of  claim 26 , wherein the osteogenerative agent is an osteoconductive agent.  
   
   
       28 . The osteogenic implant of  claim 26 , wherein the osteogenerative agent is an osteoinductive agent.  
   
   
       29 .- 32 . (canceled)  
   
   
       33 . The osteogenic implant of  claim 26 , wherein the first polymeric matrix includes a hydrogel.  
   
   
       34 . The osteogenic implant of  claim 26 , wherein the first polymeric matrix includes a bioresorbable polymer.  
   
   
       35 .- 36 . (canceled)  
   
   
       37 . The osteogenic implant of  claim 26 , further comprising an anesthetic agent.  
   
   
       38 . The osteogenic implant of  claim 37 , wherein the osteogenic implant is configured to release at least a portion of the anesthetic agent in conjunction with the degradation agent.  
   
   
       39 .- 40 . (canceled)  
   
   
       41 . A medical kit comprising: 
 an osteogenic implant including: 
 a degradation agent in solid form; and  
 an osteogenerative agent in solid form;  
 wherein the osteogenic implant is configured to release the degradation agent prior to releasing the osteogenerative agent; and  
   a tool configured to locate the osteogenic implant proximate to a vertebral structure.    
   
   
       42 . The medical kit of  claim 41 , wherein the tool includes a lumen and wherein the osteogenic implant is configured to fit within the lumen.  
   
   
       43 .- 68 . (canceled)