Murine genomic polynucleotide sequence encoding a G-protein coupled receptor and methods of use therefor

Abstract

The present invention particularly relates to a newly identified murine genomic polynucleotide that encodes an ortholog of the human P2T receptor which is expressed at high levels in the central nervous system, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. The invention relates also to identifying compounds which may be agonists, antagonists and/or inhibitors of P2T, and therefore potentially useful in therapy.

1 - 19 . (canceled)  
     
     
         20 . An antibody specific for a murine P2T receptor polypeptide comprising the amino acid sequence of SEQ ID NO:2.  
     
     
         21 . The antibody of  claim 20 , wherein the antibody is selected from the group consisting of monoclonal, polyclonal, chimeric, humanized and single chain.  
     
     
         22 . The antibody of  claim 21 , wherein the antibody is monoclonal.  
     
     
         23 . The antibody of  claim 21 , wherein the antibody is humanized.  
     
     
         24 . An antibody specific for a polynucleotide comprising the nucleic acid sequence of SEQ ID NO:1 or a degenerate variant thereof.  
     
     
         25 . The antibody of  claim 24 , wherein the antibody binds to a nucleic acid sequence comprised within nucleotide 1 to about nucleotide 45,167 of nucleic acid sequence SEQ ID NO:1 or the complement of SEQ ID NO:1.  
     
     
         26 . The antibody of  claim 25 , wherein the antibody is monoclonal, polyclonal, chimeric, humanized and single chain.  
     
     
         27 . The antibody of  claim 26 , wherein the antibody is monoclonal.  
     
     
         28 - 69 . (canceled)