Human orthologues of WART

Abstract

The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that modulate the function of an hWART polypeptide. Also disclosed are methods for diagnosing abnormal cell proliferative conditions in an organism using hWART-related molecules or compounds.

1 - 9 . (canceled)  
     
     
         10 . An isolated, enriched or purified hWART polypeptide of SEQ ID NO:4.  
     
     
         11 . The polypeptide of  claim 10 , wherein said polypeptide is a fragment of the protein encoded by the full length amino acid sequence set forth in SEQ ID NO:4.  
     
     
         12 . The polypeptide of  claim 10 , wherein said polypeptide comprises an amino acid sequence having 
 (a) the full length amino acid sequence set forth in SEQ ID NO:4;    (b) the full length amino acid sequence of the sequence set forth in SEQ ID NO:4, expect that it lacks one or more of the following segments of amino acid residues 1-33, 43-139, 342-466, 467-480, 514-518, 974-1048 of SEQ ID NO:4;    (c) the amino acid sequence set forth in SEQ ID NO:4 from amino acid residues residues 1-33, 43-139, 342-466, 467-480, 514-518, 974-1048 of SEQ ID NO:4; or    (d) the full length amino acid sequence set forth in SEQ ID NO:4 except that it lacks one or more of the domains selected from the group consisting of an N-terminal domain, a catalytic domain, and a C-terminal domain.    
     
     
         13 - 14 . (canceled)  
     
     
         15 . A method for identifying a substance capable of modulating hWART activity comprising the steps of: 
 (a) contacting a polypeptide of SEQ ID NO: 4 with a test substance; and    (b) determining whether said substance alters the activity of said polypeptide.    
     
     
         16 - 22 . (canceled)