Methods and Compositions for the Treatment of Pain and Other Hormone-Allergy-Related Symptoms Using Dilute Hormone Solutions

Abstract

A method and composition for the treatment of hormone allergy is disclosed. The method relates to using progesterone dilutions, or any other steroid hormone, to treat the systemic symptoms of hormone allergy, including pain. The composition of the hormone dilutions ranges from 10 −1 to 10 −5 . The hormone dilution may be administered sublingually, or, in the alternative, an intradermal route of administration may be chosen. Hormone dilutions may be administered at daily intervals or on any other treatment schedule as required to alleviate a patient's symptoms.

1 . A method for treating at least one symptom of a hormone allergy comprising administering sublingually to a patient in need an effective amount of a hormone dilution to treat the at least one symptom selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof.  
   
   
       2 . The method of  claim 1  wherein the hormone dilution comprises a steroid hormone solution with a concentration between approximately 5 mg/ml and 0.5 μg/ml.  
   
   
       3 . The method of  claim 2  further comprising the dilution of progesterone used to treat bone or joint pain.  
   
   
       4 . The method of  claim 2  further comprising the concentration of the hormone solution selected from the group consisting of 5 mg/ml, 0.5 mg/ml, 50 μg/ml, 5 μg/ml, and 0.5 μg/ml.  
   
   
       5 . The method of  claim 1  wherein the hormone dilution comprises an estrogen solution with a concentration between approximately 5 mg/ml and 0.5 μg/ml.  
   
   
       6 . The method of  claim 1  wherein the dilution comprises a progesterone solution with a concentration approximately between approximately 5 mg/ml and 0.5 μg/ml.  
   
   
       7 . The method of  claim 6  further comprising the amount of progesterone administered ranges from between approximately 0.5 mg to 0.05 μg per dose.  
   
   
       8 . The method of  claim 1  wherein the dilution comprises a testosterone solution with a concentration between approximately 5 mg/ml and 0.5 μg/ml.  
   
   
       9 . The method of  claim 1  wherein the at least one symptom comprises: headache, muscular pain in the head, neck, shoulders, back or legs, sinus symptoms, bone or joint pain, or any combination thereof.  
   
   
       10 . The method of  claim 1  further comprising administering the hormone dilution every day, every other day or as often as needed to alleviate symptoms.  
   
   
       11 . A method for treating a hormone allergy comprising: 
 administering a dilution of progesterone with a concentration ranging between approximately 5 mg/ml to 0.5 μg/ml;    administering the dose sublingually to a patient; and    administering additional dilutions of progesterone as often as necessary to stimulate an effective response.    
   
   
       12 . The method of  claim 11  further comprising treating a symptom selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof.  
   
   
       13 . A method of blocking pain perception in a patient's brain comprising administering sublingually a dilute hormone solution with a concentration between approximately 5 mg/ml and 0.5 μg/ml of the hormone.  
   
   
       14 . The method of  claim 13  wherein the hormone solution comprises dilute progesterone.  
   
   
       15 . The method of  claim 13  wherein the hormone solution comprises dilute estrogen.  
   
   
       16 . The method of  claim 13  wherein in the hormone solution comprises dilute testosterone.  
   
   
       17 . A method of determining an appropriate sublingual steroid hormone dilution for treatment of a hormone allergy comprising: 
 ranking the severity of at least one symptom;    administering sublingually increasing concentrations of a dilute hormone solution to a patient;    ranking the severity of the at least one symptom again after sublingual administration of each concentration of the steroid hormone dilution;    each concentration of the steroid hormone dilution between approximately 5 mg/ml and 0.5 μg/ml; and    the concentration at which symptoms improve or are alleviated corresponding with an appropriate dose for a respective patient.    
   
   
       18 . The method of  claim 17  wherein the steroid hormone comprises progesterone.  
   
   
       19 . The method of  claim 17  further comprising ranking the symptom using a numeric scale.  
   
   
       20 . The method of  claim 17  further comprising the increasing concentrations of hormone dilution from approximately between 0.5 μg/ml, 5 μg/ml, 50 μg/ml, 0.5 mg/ml, and 5 mg/ml.  
   
   
       21 . A composition for the treatment of hormone allergy comprising: 
 a hormone solution having a concentration between approximately 0.5 μg/ml and 5 mg/ml;    the hormone solution including at least normal saline; and    the hormone solution operable to treat a symptom from a group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof.    
   
   
       22 . The composition of  claim 21  wherein the hormone comprises progesterone.  
   
   
       23 . The composition of  claim 21  wherein the hormone comprises testosterone.  
   
   
       24 . A composition for the treatment of hormone allergy comprising: 
 a hormone solution with a concentration between approximately 0.5 μg/ml and 5 mg/ml;    the hormone solution operable to be administered sublingually;    the hormone solution operable to treat at least one symptom from a group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof; and    severity of the symptom ranked before treatment by a patient.    
   
   
       25 . The composition of  claim 24  wherein the hormone comprises progesterone.  
   
   
       26 . The composition of  claim 24  wherein the hormone comprises testosterone.  
   
   
       27 . The composition of  claim 24  comprising the at least one symptom ranked with a numeric scale.  
   
   
       28 . A method for treating pain comprising: 
 administering a dilution of progesterone with a concentration ranging from between approximately 5 mg/ml to 0.5 μg/ml;    administering the dose sublingually to a patient; and    administering additional dilutions of progesterone as often as necessary to stimulate an effective response.    
   
   
       29 . The method of  claim 28  further comprising treating a symptom selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof.  
   
   
       30 . A method of determining an appropriate sublingual steroid hormone dilution for treatment of pain comprising: 
 ranking the severity of at least one symptom;    administering sublingually increasing concentrations of a dilute hormone solution to a patient;    ranking the severity of the at least one symptom again after sublingual administration of each concentration of the steroid hormone dilution;    each concentration of the steroid hormone dilution between approximately 5 mg/ml and 0.5 μg/ml; and    the concentration at which symptoms improve or are alleviated corresponding with an appropriate dose for a respective patient.    
   
   
       31 . The method of  claim 30  wherein the steroid hormone comprises progesterone.  
   
   
       32 . The method of  claim 30  further comprising ranking the symptom using a numeric scale.  
   
   
       33 . The method of  claim 30  further comprising the increasing concentrations of hormone dilution from approximately between 0.5 μg/ml, 5 μg/ml, 50 μg/ml, 0.5 mg/ml, and 5 mg/ml.  
   
   
       34 . The method of  claim 30  further comprising the amount of progesterone administered ranges from between approximately 0.5 mg to 0.05 μg.  
   
   
       35 . A method for treating at least one symptom of a hormone allergy comprising administering sublingually to a patient in need an effective amount of a hormone dilution, wherein the at least one symptom is selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof and wherein relief of the at least one symptom occurs in about 20 seconds after administration.  
   
   
       36 . A method for treating at least one symptom of a hormone allergy comprising administering sublingually to a subject about 0.1 milliliter of a 0.05 milligram per milliliter dilution of a hormone selected from the group consisting of estrogen and progesterone, wherein the at least one symptom is selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof, wherein relief of the at least one symptom occurs in about 20 seconds after administration, and wherein the subject experiences at least about a 57% reduction in the at least one symptom on average.  
   
   
       37 . A method for treating at least one symptom of a hormone allergy comprising administering sublingually to a subject about 0.1 milliliter of a 0.05 milligram per milliliter dilution of a hormone selected from the group consisting of estrogen and progesterone, wherein the at least one symptom is selected from the group consisting of shortness of breath, nasal congestion, eye irritation, headache, pain in the head, neck, shoulders, back, arms, legs and joints and any combination thereof, wherein relief of the at least one symptom occurs in about 20 seconds after administration and lasts for at least about twelve to about twenty-four hours.  
   
   
       38 . A method for treating at least one symptom of a hormone allergy comprising administering sublingually to a patient in need an effective amount of a hormone dilution, wherein the at least one symptom comprises shortness of breath, wherein relief of the at least one symptom occurs in about 20 seconds after administration, and wherein the subject's air flow, lung volume, or both air flow and lung volume are higher after treatment.