Surface treatment

Abstract

Described is a process for producing a biomolecular monolayer on a biosensor surface comprising the steps of: reacting a biosensor surface with a solution of heterobifunctional reagent having a first functional group and a second functional group, the first functional group being capable of forming a covalent bond to the biosensor surface groups, the second functional group forming a covalent bond with a homobifunctional polymer to obtain a self-assembled monolayer, and thereafter reacting the monolayer with capture molecules.

1 .- 16 . (canceled)  
     
     
         17 . A biosensor array comprising a patterned deposit of biomolecules on a substrate wherein the patterned deposit is formed by a process for producing a biomolecular monolayer on a surface comprising the steps of: reacting the surface with a solution of a heterobifunctional reagent having a first functional group and a second functional group, the first functional group being capable of forming a covalent bond to surface groups, the second functional group forming a covalent bond with a homobifunctional polymer to obtain a self-assembled monolayer, and thereafter reacting the monolayer with capture molecules.  
     
     
         18 . A biochip having a surface layer formed by a process for producing a biomolecular monolayer on a surface comprising the steps of: reacting the surface with a solution of a heterobifunctional reagent having a first functional group and a second functional group, the first functional group being capable of forming a covalent bond to surface groups, the second functional group forming a covalent bond with a homobifunctional polymer to obtain a self-assembled monolayer, and thereafter reacting the monolayer with biomolecules.  
     
     
         19 . A biochip array comprising a patterned deposit of biomolecules on a substrate wherein the patterned deposit is formed by a process for producing a biomolecular monolayer on a surface comprising the steps of: reacting the surface with a solution of a heterobifunctional reagent having a first functional group and a second functional group, the first functional group being capable of forming a covalent bond to surface groups, the second functional group forming a covalent bond with a homobifunctional polymer to obtain a self-assembled monolayer, and thereafter reacting the monolayer with biomolecules.