Oral GLP-1 formulations

Abstract

The present invention provides phamaceutical compositions comprising at least one delivery agent and GLP-1. These pharmaceutical compositions facilitate the oral delivery of GLP-1, providing improved (e.g. increased) bioavailability of GLP-1 compared to administration of GLP-1 without a delivery agent.

1 . A formulation comprising a GLP-1 compound and a delivery agent selected from the group consisting of Delivery agent 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 17, 18, 20, 21, 22, 23, 24, 25, 26, 27, 28, and 29.  
     
     
         2 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, and SEQ ID NO: 14.  
     
     
         3 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 12, SEQ ID NO: 13, and SEQ ID NO: 14.  
     
     
         4 . The formulation of  claim 1 , wherein the GLP-1 compound is selected from the group consisting of GLP-1 compounds of SEQ ID NO: 2, SEQ ID NO: 12, SEQ ID NO: 13, and SEQ ID NO: 14.  
     
     
         5 . The formulation of  claim 1 , wherein the GLP-1 compound is of SEQ ID NO:13 or SEQ ID NO: 14.