Retinoid solutions and formulations made therefrom

Abstract

Compositions for topical application for treating a skin disorder (e.g., acne) include a retinoid, which is solubilized completely in alcohol only with the aid of cosolvents such as esters (e.g., alkyl benzoate, isopropyl palmitate, isopropyl myristate, diisopropyl adipate and their derivatives). This completely solubilized retinoid can be used to formulate an emulsion system or liquid to powder suspension containing a second active, such as an antibiotic (e.g., clindamycin).

1 . A method of treating acne comprising applying to the skin of a subject afflicted with acne a composition comprising a solution, the solution comprising a retinoid, an anhydrous alcohol and an ester capable of solubilizing the retinoid in the presence of the anhydrous alcohol, wherein the amount of anhydrous alcohol is insufficient alone to solubilize the retinoid.  
     
     
         2 . A method as in  claim 1  wherein the composition is an emulsion comprising an aqueous phase containing a water soluble active ingredient and a non-aqueous phase containing the solution.  
     
     
         3 . A method as in  claim 1  wherein the composition is an emulsion comprising an aqueous phase containing clyndamycin, water and glycerine and a non-aqueous phase containing the solution.  
     
     
         4 . A method as in  claim 1  wherein the composition is a suspension comprising a mixture of volatile silicone and starch and the solution.  
     
     
         5 . A method as in  claim 1  wherein the composition is a suspension comprising a mixture of volatile silicone and starch, the solution and an aqueous phase containing clyndamycin, water, propylene glycol and glycerine.  
     
     
         6 . An apparatus comprising: 
 a first chamber containing a first composition, the first composition comprising a solution, the solution comprising retinoid, an anhydrous alcohol and an ester capable of solubilizing the retinoid in the presence of the anhydrous alcohol, wherein the amount of anhydrous alcohol is insufficient alone to solubilize the retinoid;    a second chamber containing a second composition comprising an active ingredient selected from the group consisting of antibiotics;    means for selectively interconnecting the first and second chambers to allow mixing of the first and second compositions; and    at least one outlet for dispensing a mixture of the first and second compositions.