US2006275796A1PendingUtilityA1

Canine herpesvirus thymidine kinase nucleic acid molecules

56
Individually held — no corporate assignee on recordPriority: Feb 15, 1996Filed: Mar 13, 2006Published: Dec 7, 2006
Est. expiryFeb 15, 2016(expired)· nominal 20-yr term from priority
Inventors:Elizabeth J. HaanesRexann S. Frank
C12N 9/1211A61P 31/00A61P 31/04C12N 2710/16721C07K 14/005A61P 37/00A61P 31/22C12N 2710/16743C12N 2710/16722A61P 33/00A61P 31/10C12N 7/00C12N 15/86
56
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Claims

Abstract

The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.

Claims

exact text as granted — not AI-modified
1 - 83 . (canceled)  
     
     
         84 . An isolated nucleic acid molecule that hybridizes under stringent hybridization conditions with a nucleic acid molecule having the sequence of SEQ ID NO:35 or SEQ ID NO:37.  
     
     
         85 . The isolated nucleic acid molecule of  claim 84 , wherein said CHV nucleic acid molecule comprises a nucleic acid sequence at least about 80% identical to SEQ ID NO:35, SEQ ID NO:37 or SEQ ID NO:38.  
     
     
         86 . The isolated nucleic acid molecule of  claim 84 , wherein said isolated nucleic acid molecule comprises a nucleic acid sequence at least about 90% identical to SEQ ID NO:35, SEQ ID NO:37 or SEQ ID NO:38.  
     
     
         87 . The isolated nucleic acid molecule of  claim 84 , wherein said CHV nucleic acid molecule comprises a nucleic acid sequence at least about 95% identical to SEQ ID NO:35, SEQ ID NO:37 or SEQ ID NO:38.  
     
     
         88 . The isolated nucleic acid molecule of  claim 84 , wherein said CHV nucleic acid molecule comprises a nucleic acid sequence selected from the group consisting of SEQ ID NO:35, SEQ ID NO:37, SEQ ID NO:38, and a nucleic acid molecule comprising an allelic variant of any of said nucleic acid molecules.  
     
     
         89 . The isolated nucleic acid molecule of  claim 84 , wherein said molecule encodes a protein having thymidine kinase activity.  
     
     
         90 . An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a protein at least about 95% identical to SEQ ID NO:36.  
     
     
         91 . The isolated nucleic acid molecule of  claim 90  wherein said protein has thymidine kinase activity.  
     
     
         92 . The isolated nucleic acid molecule of  claim 90 , wherein said nucleic acid sequence encodes a protein having an amino acid sequence selected from the group consisting of SEQ ID NO:36 and an amino acid sequence which is an allelic variant of SEQ ID NO:36.  
     
     
         93 . The isolated nucleic acid molecule of  claim 90 , wherein said nucleic acid sequence encodes a protein having the amino acid sequence of SEQ ID NO:36.  
     
     
         94 . The isolated nucleic acid molecule of  claim 90 , wherein said nucleic acid sequence is at least about 95% identical to SEQ ID NO:35 or SEQ ID NO:38.  
     
     
         95 . The isolated nucleic acid molecule of  claim 90 , wherein said nucleic acid sequence is at least about 99% identical to SEQ ID NO:35 or SEQ ID NO:38.  
     
     
         96 . The isolated nucleic acid molecule of  claim 90 , wherein said nucleic acid sequence is identical to SEQ ID NO:35 or SEQ ID NO:38.  
     
     
         97 . An isolated nucleic acid molecule consisting of a nucleic acid sequence selected from the group consisting of: 
 (a) a nucleic acid sequence encoding a protein at least about 95% identical to SEQ ID NO:36; and    (b) a nucleic acid sequence fully complimentary to the sequence of (a).    
     
     
         98 . The isolated nucleic acid molecule of  claim 97 , wherein said nucleic acid sequence encodes a protein having an amino acid sequence selected from the group consisting of SEQ ID NO:36 and an amino acid sequence which is an allelic variant of SEQ ID NO:36.  
     
     
         99 . The isolated nucleic acid molecule of  claim 97 , wherein said nucleic acid sequence encodes a protein having the amino acid sequence of SEQ ID NO:36.  
     
     
         100 . The isolated nucleic acid molecule of  claim 97 , wherein said nucleic acid sequence is at least about 95% identical to SEQ ID NO:35, SEQ ID NO:37 or SEQ ID NO:38.  
     
     
         101 . The isolated nucleic acid molecule of  claim 97 , wherein said nucleic acid sequence is at least about 99% identical to SEQ ID NO:35, SEQ ID NO:37 or SEQ ID NO:38.  
     
     
         102 . A fragment of the isolated nucleic acid molecule of  claim 97 , wherein said fragment is at least 18 nucleotides in length.

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