Large capacity acid or base generator and method of use

Abstract

Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

1 . An apparatus for generating an acid or base comprising: 
 (a) an ion source reservoir containing a source of either anions or cations including inlet and outlet ports,    (b) an acid or base generation chamber having inlet and outlet ports,    (c) a charged first barrier disposed between said ion source reservoir and said acid or base generation chamber, said barrier substantially preventing liquid flow while providing an ion transport bridge for only ions of one charge, positive or negative,    (d) a first electrode in electrical communication with said ion source reservoir,    (e) a second electrode in electrical communication with said first acid or base generation chamber,    (f) an aqueous liquid source in fluid communication with said acid or base generation chamber inlet port,    (g) a remote reservoir for ion-containing solution having inlet and outlet ports,    (h) a pump for pumping ion-containing solution from said remote reservoir outlet port to said ion source reservoir inlet port,    (i) a recycle conduit connecting said ion source reservoir outlet port and said remote reservoir inlet port, and    (j) apparatus for using solution generated in said acid or base generation chamber in communication with said acid or base generation chamber outlet, said using apparatus being selected from the group consisting of a chromatographic separator, a titrator, a flow injection analysis apparatus, and a post-column reactor for liquid chromatography.    
     
     
         2 . The apparatus of  claim 1  in which said using apparatus comprises a chromatographic separator.  
     
     
         3 . The apparatus of  claim 1 , in which said generated acid or base is used as an eluent stream for analysis of samples containing components of interest, said apparatus further comprising: 
 (k) a sample injection port for injecting a liquid sample stream of ions to be detected,    (l) a chromatographic separator for separating said components of interest, and having inlet and outlet ports, said inlet port being in fluid communication with said sample injection port and said acid or base generator outlet port, whereby a chromatography effluent exits from said outlet port, and    (m) a detector in fluid communication with said chromatographic separator for detecting the separated components of interest in said chromatography effluent.    
     
     
         4 . The apparatus of  claim 3  further comprising: 
 (l) a gradient pump for pumping one or more gradient eluents into said ion-containing solution generated in said first acid or base generation chamber.    
     
     
         5 . The apparatus of  claim 3  further comprising: 
 (n) a flow restrictor in fluid communication with the outlet of said first acid or base generation chamber outlet port.    
     
     
         6 . The apparatus of  claim 1 , further comprising: 
 (k) a bed of ion exchange resin with exchangeable ions of the same charge as said first barrier disposed in said generation chamber between said first barrier and said second electrode and providing an ion path therebetween.    
     
     
         7 . The apparatus of  claim 1 , further comprising: 
 (k) an ion source comprising a bed of ion exchange resin with exchangeable ions of the same charge as said first barrier disposed in said generation chamber between said first barrier and said second electrode and providing an ion path therebetween.    
     
     
         8 . An apparatus for generating an acid or base comprising: 
 (a) an ion source reservoir containing a source of either anions or cations,    (b) an acid or base generation chamber having inlet and outlet ports,    (c) a charged first barrier disposed between said ion source reservoir and said acid or base generation chamber, said barrier substantially preventing liquid flow while providing an ion transport bridge for only ions of one charge, positive or negative,    (d) a first electrode in electrical communication with said ion source reservoir,    (e) a second electrode in electrical communication with said first acid or base generation chamber, and    (f) an aqueous liquid source in fluid communication with said acid or base generation chamber inlet port,    (g) a pump upstream of said acid or base generation chamber inlet port and in fluid communication therewith, and    (h) apparatus for using solution generated in said acid or base generation chamber in communication with said acid or base generation chamber outlet, said using apparatus being selected from the group consisting of a chromatographic separator, a titrator, a flow injection analysis apparatus, and a post-column reactor for liquid chroamtography.    
     
     
         9 . The apparatus of  claim 8  in which said using apparatus comprises a chromatographic separator.  
     
     
         10 . The apparatus of  claim 8 , in which said generated acid or base is used as an eluent stream for analysis of samples containing components of interest, said apparatus further comprising: 
 (i) a sample injection port for injecting a liquid sample stream of ions to be detected,    (j) a chromatographic separator for separating said components of interest, and having inlet and outlet ports, said inlet port being in fluid communication with said sample injection port and said acid or base generator outlet port, whereby a chromatography effluent exits from said outlet port, and    (k) a detector in fluid communication with said chromatographic separator for detecting the separated components of interest in said chromatography effluent.    
     
     
         11 . The apparatus of  claim 10  further comprising: 
 (l) a gradient pump for pumping one or more gradient eluents into said ion-containing solution generated in said first acid or base generation chamber.    
     
     
         12 . The apparatus of  claim 10  further comprising: 
 (l) a flow restrictor in fluid communication with the outlet of said first acid or base generation chamber outlet port.