US2006264372A1PendingUtilityA1

Process for the synchronization of ovulation for timed breeding without heat detection

58
Individually held — no corporate assignee on recordPriority: Oct 3, 2003Filed: Feb 17, 2006Published: Nov 23, 2006
Est. expiryOct 3, 2023(expired)· nominal 20-yr term from priority
Inventors:Stephen Kent WebelJames W. Lauderdale
A61P 15/08A61K 9/06A61K 38/24A61K 38/09A61K 9/10A61K 9/08A61K 9/0034A61K 9/0019A61D 19/02
58
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Claims

Abstract

A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles. The sow is then bred, without heat detection, at a specific subsequent timed interval after injection with hormone, with one or two artificial or natural breedings. In gilts, the hormone is injected at a timed interval from onset of estrus or at a specific timed interval following Prostaglandin F2a for those gilts which have been held in a state of pseudopregnancy.

Claims

exact text as granted — not AI-modified
1 . A method for synchronizing time of insemination in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a pubertal gilt on the first day of estrus, and steps (a) and (b) are performed without further heat detection.    
     
     
         2 . The method of  claim 1 , wherein the hormone is administered at the first detectable sign of estrus.  
     
     
         3 . The method of  claim 1 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         4 . A method for synchronizing time of insemination in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pseudopregnancy and has been administered a dose of Prostaglandin F2a.    
     
     
         5 . The method of  claim 4 , wherein the hormone is administered 48 hours after Prostaglandin F2a administration.  
     
     
         6 . The method of  claim 4 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         7 . A method for synchronizing time of insemination in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pregnancy and has been administered Prostaglandin F2a for the purpose of synchronized abortion.    
     
     
         8 . The method of  claim 7 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         9 . The method of  claim 7 , wherein the hormone is administered 48 hours after abortion is completed.  
     
     
         10 . A composition for synchronizing time of insemination in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is selected from the group of excipients consisting of sucrose acetate isobutyrate and block copolymers based on ethylene oxide and propylene oxide.  
     
     
         11 . A composition for synchronizing time of insemination in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is selected from the group consisting of collagen, hyaluronic acid, alginate, and fibrin.  
     
     
         12 . A composition for synchronizing time of insemination in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the hormone is administered in a medical depot device or polymeric delivery device.  
     
     
         13 . A composition for synchronizing time of insemination in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, and an ion exchange resin to sustain release.  
     
     
         14 . A composition for synchronizing time of insemination in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the composition is releasing hormone for at least one day.  
     
     
         15 . A composition for synchronizing time of insemination in swine without heat detection, comprising gonadotropin releasing hormone (GnRH), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is sucrose acetate isobutyrate.  
     
     
         16 . A kit for synchronizing time of insemination in swine comprising 
 a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, and    Prostaglandin F2a.    
     
     
         17 . A method for synchronizing ovulation in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a pubertal gilt on the first day of estrus, and steps (a) and (b) are performed without further heat detection.    
     
     
         18 . The method of  claim 17 , wherein the hormone is administered at the first detectable sign of estrus.  
     
     
         19 . The method of  claim 17 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         20 . A method for synchronizing ovulation in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pseudopregnancy and has been administered a dose of Prostaglandin F2a.    
     
     
         21 . The method of  claim 20 , wherein the hormone is administered 48 hours after Prostaglandin F2a administration.  
     
     
         22 . The method of  claim 20 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         23 . A method for synchronizing ovulation in swine without heat detection, the steps comprising: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pregnancy and has been administered Prostaglandin F2a for the purpose of synchronized abortion.    
     
     
         24 . The method of  claim 23 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         25 . The method of  claim 23 , wherein the hormone is administered 48 hours after abortion is completed.  
     
     
         26 . A composition for synchronizing ovulation in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is selected from the group of excipients consisting of sucrose acetate isobutyrate and block copolymers based on ethylene oxide and propylene oxide.  
     
     
         27 . A composition for synchronizing ovulation in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is selected from the group consisting of collagen, hyaluronic acid, alginate, and fibrin.  
     
     
         28 . A composition for synchronizing ovulation in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the hormone is administered in a medical depot device or polymeric delivery device.  
     
     
         29 . A composition for synchronizing ovulation in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, and an ion exchange resin to sustain release.  
     
     
         30 . A composition for synchronizing ovulation in swine without heat detection, comprising: a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the composition is releasing hormone for at least one day.  
     
     
         31 . A composition for synchronizing ovulation in swine without heat detection, comprising gonadotropin releasing hormone (GnRH), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, wherein the excipient is sucrose acetate isobutyrate.  
     
     
         32 . A kit for synchronizing ovulation in swine comprising 
 a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation, in an excipient suitable for intravaginal administration, and    Prostaglandin F2a.    
     
     
         33 . A method for synchronizing time of insemination in swine without heat detection, the steps consisting essentially of: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a pubertal gilt and the hormone is administered on the first day of estrus, and steps (a) and (b) are performed without further heat detection.    
     
     
         34 . The method of  claim 33 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         35 . A method for synchronizing time of insemination in swine without heat detection, the steps consisting essentially of: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pseudopregnancy and has been administered a dose of Prostaglandin F2a.    
     
     
         36 . The method of  claim 35 , wherein the hormone is administered 48 hours after Prostaglandin F2a administration.  
     
     
         37 . The method of  claim 35 , wherein a second breeding is performed subsequent to the breeding in 1(b).  
     
     
         38 . A method for synchronizing time of insemination in swine without heat detection, the steps consisting essentially of: 
 (a) administering to a swine a dose of a hormone selected from the group consisting of a gonadotropin releasing hormone (GnRH), a luteinizing hormone (LH), a human chorionic gonadotropin (hCG), derivatives and analogues thereof, and combinations thereof, in an amount effective to stimulate ovarian follicle ovulation; and    (b) after approximately one day, breeding the sow without heat detection;    wherein the swine is a gilt in a state of pregnancy and has been administered Prostaglandin F2a for the purpose of synchronized abortion.    
     
     
         39 . The method of  claim 38 , wherein the hormone is administered 48 hours after abortion is completed.  
     
     
         40 . The method of  claim 38 , wherein a second breeding is performed subsequent to the breeding in 1(b).

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