Methods and Devices for Contributing to the Treatment of Aneurysms

Abstract

The present invention relates to methods and devices to contribute to the treatment of aneurysms. More specifically, the present invention relates to methods and devices to contribute to contribute to the treatment of aneurysms by delivering bioactive agents via various delivery devices of collagen III and/or collagen III and thrombin.

1 . A method comprising contributing to the treatment of an aneurysm by placing a ribbon that administers collagen III at the aneurysm site.  
     
     
         2 . A method according to  claim 1  wherein said ribbon administers collagen III and an additional bioactive agent.  
     
     
         3 . A method according to  claim 2  wherein said additional bioactive agent is selected from one or more of the group consisting of collagen I, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), plated-derived epidermal growth factor (PDEGF), basic fibroblast growth factor (bFGF), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β), platelet-derived angiogenesis growth factor (PDAF) and autologous platelet gel (APG) including platelet rich plasma (PRP) and platelet poor plasma (PPP) and thrombin.  
     
     
         4 . A method according to  claim 1 , wherein said ribbon is a polymer ribbon.  
     
     
         5 . A method according to  claim 1  wherein said ribbon further comprises an osmotic mini-pump.  
     
     
         6 . A method according to  claim 5  wherein said osmotic mini-pump releases a bioactive agent.  
     
     
         7 . A method according to  claim 6  wherein said bioactive agent is selected from one or more of the group consisting of collagen I, collagen III, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), plated-derived epidermal growth factor (PDEGF), basic fibroblast growth factor (bFGF), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β), platelet-derived angiogenesis growth factor (PDAF) and autologous platelet gel (APG) including platelet rich plasma (PRP) and platelet poor plasma (PPP) and thrombin.  
     
     
         8 . A method according to  claim 1  further comprising deployment of a stent graft at said aneurysm site.  
     
     
         9 . A method according to  claim 1  wherein said method further comprises administering flowable collagen III to said aneurysm site through an injection catheter.  
     
     
         10 . A method according to  claim 9  wherein said method further comprises administering flowable thrombin to said aneurysm site through an injection catheter.  
     
     
         11 . A method according to  claim 9  further comprising deployment of a stent graft at said aneurysm site.  
     
     
         12 . A ribbon comprising collagen III wherein said ribbon is deployed at an aneurysm site in conjunction with a treatment selected from the group consisting of the administration of flowable collagen III to said aneurysm site through an injection catheter; the deployment of a stent graft at said aneurysm site; and the administration of flowable collagen III to said aneurysm site through an injection catheter and the deployment of a stent graft at said aneurysm site.  
     
     
         13 . A ribbon according to  claim 12  wherein said ribbon administers collagen III and an additional bioactive agent.  
     
     
         14 . A ribbon according to  claim 13  wherein said bioactive agent is selected from one or more of the group consisting of collagen I, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), plated-derived epidermal growth factor (PDEGF), basic fibroblast growth factor (bFGF), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β), platelet-derived angiogenesis growth factor (PDAF) and autologous platelet gel (APG) including platelet rich plasma (PRP) and platelet poor plasma (PPP) and thrombin.  
     
     
         15 . A ribbon according to  claim 12  wherein said ribbon is a polymer ribbon.  
     
     
         16 . A ribbon according to  claim 12  wherein said ribbon further comprises an osmotic mini-pump.  
     
     
         17 . A ribbon according to  claim 16  wherein said osmotic mini-pump releases a bioactive agent.  
     
     
         18 . A ribbon according to  claim 17  wherein said bioactive agent is selected from one or more of the group consisting of collagen I, collagen III, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), plated-derived epidermal growth factor (PDEGF), basic fibroblast growth factor (bFGF), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β), platelet-derived angiogenesis growth factor (PDAF) and autologous platelet gel (APG) including platelet rich plasma (PRP) and platelet poor plasma (PPP) and thrombin.  
     
     
         19 . A ribbon according to  claim 12  wherein when said flowable collagen III is administered to said aneurysm site through an injection catheter, flowable thrombin is also administered to said aneurysm site through an injection catheter.