US2006241165A1PendingUtilityA1

Method and kit for regulation of microvascular tone

58
Assignee: MOORE BOB M IIPriority: May 12, 2003Filed: Jun 29, 2006Published: Oct 26, 2006
Est. expiryMay 12, 2023(expired)· nominal 20-yr term from priority
Inventors:Bob M. Moore, Ii
A61P 43/00A61P 9/02A61P 9/10A61P 9/00A61K 31/42A61K 31/444A61K 31/353A61K 45/06A61K 31/16A61P 17/02A61K 31/542A61K 31/341A61K 31/405A61K 31/5415A61K 31/415A61K 31/25A61K 31/18A61K 31/658
58
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Claims

Abstract

Methods and kits for regulating arterial microvascular tone in which a COX-2 inhibitor and a cannabinoid receptor agonist are co-administered to a subject.

Claims

exact text as granted — not AI-modified
1 . A method for causing construction of arterial microvasculature comprising administering to a vertebrate subject an effective amount of a chemical compound that has cannabinoid receptor agonist activity and COX-2 inhibitory activity.  
   
   
       2 . The method of  claim 1  wherein the subject is a mammal.  
   
   
       3 . The method of  claim 2  wherein the mammal is a human.  
   
   
       4 . The method of  claim 1  wherein the chemical compound further comprises COX-1 inhibitory activity.  
   
   
       5 . The method of  claim 1  wherein the chemical compound comprises ajulemic acid.  
   
   
       6 . The method of  claim 1  wherein the administration of the chemical compound is systemic.  
   
   
       7 . The method of  claim 1  wherein the microvasculature is striated muscle microvasculature.  
   
   
       8 . A method for increasing blood pressure in a subject comprising administering a chemical compound that has cannabinoid receptor agonist activity and COX-2 inhibitory activity in an amount effective to increase blood pressure in the subject.  
   
   
       9 . The method of  claim 8  wherein the subject is a mammal.  
   
   
       10 . The method of  claim 9  wherein the mammal is a human.  
   
   
       11 . The method of  claim 8  wherein, at the time of the administration, the subject is suffering from an acute decrease in blood pressure.  
   
   
       12 . A method for treating a subject suffering from or at risk of developing shock comprising administering to a vertebrate subject in need thereof a chemical compound having cannabinoid receptor agonist activity and COX-2 inhibitor activity.  
   
   
       13 . The method of  claim 12  wherein the chemical compound further comprises COX-1 inhibitor activity.  
   
   
       14 . The method of  claim 12  wherein the chemical compound comprises ajulemic acid.  
   
   
       15 . The method of  claim 12  wherein the administration of the chemical compound is systemic.  
   
   
       16 . The method of  claim 12  wherein the subject is a mammal.  
   
   
       17 . The method of  claim 16  wherein the mammal is a human.  
   
   
       18 . The method of  claim 12  wherein the shock is hemorrhagic shock.  
   
   
       19 . The method of  claim 12  wherein the administration is to control hypotension associated with anesthetic agents.

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