Use of A33 antigens and JAM-it

Abstract

The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.

1 . A method of treating an inflammatory disorder characterized by elevated expression of the polypeptide of SEQ ID NO: 32 in a mammal, comprising administering to said mammal an effective amount of an immunoadhesin comprising an extracellular domain sequence of the polypeptide of SEQ ID NO: 32, whereby said inflammatory disease is treated.  
     
     
         2 . The method of  claim 1  wherein said immunoadhesin comprises said extracellular domain sequence fused to an immunoglobulin constant region sequence.  
     
     
         3 . The method of  claim 2  wherein said extracellular domain sequence is essentially free of transmembrane domain sequences.  
     
     
         4 . The method of  claim 2  wherein said immunoglobulin is an IgG.  
     
     
         5 . The method of  claim 4  wherein said IgG is IgG1 or IgG3.  
     
     
         6 . The method of  claim 1  wherein said mammal is human.  
     
     
         7 . The method of  claim 6  wherein said inflammatory disorder is selected from the group consisting of rheumatoid arthritis, pneumonia, chronic asthma, chronic hepatitis, and osteoarthritis.