US2006204543A1PendingUtilityA1

Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents

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Assignee: ALLERGAN INCPriority: Jun 2, 1995Filed: May 12, 2006Published: Sep 14, 2006
Est. expiryJun 2, 2015(expired)· nominal 20-yr term from priority
Inventors:Vernon G. WongFrank Kochinke
A61K 9/0051A61K 9/0048A61P 29/00A61F 2210/0004A61K 9/0024A61P 31/04A61K 47/34A61P 27/02A61K 9/2013A61K 9/204A61K 9/2054A61F 9/0017A61P 35/00A61P 31/12
69
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Claims

Abstract

Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.

Claims

exact text as granted — not AI-modified
1 - 9 . (canceled)  
     
     
         10 . A biodegradable ocular implant comprising an active agent and a biodegradable polymer, wherein the active agent is a cyclosporine, the biodegradable polymer is a polylactic acid, polyglycolic acid co-polymer, and the implant being formed for subconjunctival insertion.  
     
     
         11 . The biodegradable ocular implant of  claim 10  wherein the polylactic acid, polyglycolic acid co-polymer is present in an amount of at least about 20 weight percent of the implant.  
     
     
         12 . The biodegradable ocular implant of  claim 10  wherein the cyclosporine is dispersed within the polylactic polyglycolic acid co-polymer.  
     
     
         13 . The biodegradable ocular implant of  claim 10  wherein the implant is made by an extrusion method.  
     
     
         14 . The biodegradable ocular implant of  claim 10  wherein the implant includes forms selected from the group consisting of sheets, pluralities of particles, fibers, microcapsules, discs, microspheres and filaments.  
     
     
         15 . The biodegradable ocular implant of  claim 10  wherein the implant includes forms selected from the group consisting of pluralities of particles and microspheres.  
     
     
         16 . The biodegradable ocular implant of  claim 10  wherein the active agent is homogeneously distributed through the biodegradable polymer.  
     
     
         17 . The biodegradable ocular implant of  claim 10  wherein the implant is sized or shaped to be compatible with the site of insertion.  
     
     
         18 . The biodegradable ocular implant of  claim 10  wherein the implant is dimensioned to be compatible with the size and shape of the site of insertion.  
     
     
         19 . The biodegradable ocular implant of  claim 10  wherein the implant is structured to facilitate both subconjunctival insertion and accommodation of the implant.  
     
     
         20 . A biodegradable ocular implant comprising an active cyclosporine and a biodegradable polylactic acid, polyglycolic acid copolymer, the implant being sized and shaped for subconjunctival insertion.  
     
     
         21 . The biodegradable ocular implant of  claim 20  wherein the implant is structured to facilitate both subconjunctival insertion and accommodation of the implant.  
     
     
         22 . The biodegradable ocular implant of  claim 20  wherein the implant is dimensioned to be compatible with the size and shape of the site of insertion.  
     
     
         23 . The biodegradable ocular implant of  claim 20  wherein the polylactic acid, polyglycolic acid co-polymer is present in an amount of at least about 20 weight percent of the implant.  
     
     
         24 . The biodegradable ocular implant of  claim 20  wherein the cyclosporine is dispersed within the polylactic polyglycolic acid co-polymer.  
     
     
         25 . The biodegradable ocular implant of  claim 20  wherein the implant is made by an extrusion method.  
     
     
         26 . The biodegradable ocular implant of  claim 20  wherein the implant includes forms selected from the group consisting of sheets, pluralities of particles, fibers, microcapsules, discs, microspheres and filaments.  
     
     
         27 . The biodegradable ocular implant of  claim 20  wherein the implant includes forms selected from the group consisting of pluralities of particles and microspheres.  
     
     
         28 . The biodegradable ocular implant of  claim 20  wherein the active agent is homogeneously distributed through the biodegradable polymer.  
     
     
         29 . The biodegradable ocular implant of  claim 20  wherein the cyclosporine is present in an amount in a range of at least about 1 weight percent to about 80 weight percent of the implant.

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