US2006173029A1PendingUtilityA1

Oxycodone hydrochloride having less than 25 ppm 14- hydroxycodeinone

65
Assignee: EURO CELTIQUE SAPriority: Mar 30, 2004Filed: Mar 29, 2006Published: Aug 3, 2006
Est. expiryMar 30, 2024(expired)· nominal 20-yr term from priority
Inventors:Robert ChapmanLonn S. RiderQi-Zhong HongDonald J. KyleRobert Kupper
A61P 29/00A61P 25/04A61K 31/485A61K 9/4833A61K 9/2095C07D 489/08A61K 9/20C07D 489/02A61K 9/14A61K 9/48A61K 9/0053C07D 489/04A61K 47/30
65
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Claims

Abstract

In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

Claims

exact text as granted — not AI-modified
1 - 70 . (canceled)  
   
   
       71 . An oxycodone hydrochloride composition having a 14-hydroxycodeinone level in an amount of less than 25 ppm.  
   
   
       72 . The oxycodone hydrochloride composition of  claim 71 , having a 14-hydroxycodeinone level in an amount of less than 15 ppm.  
   
   
       73 . The oxycodone hydrochloride composition of  claim 71 , having a 14-hydroxycodeinone level in an amount of less than 10 ppm.  
   
   
       74 . The oxycodone hydrochloride composition of  claim 71 , having a 14-hydroxycodeinone level in an amount of less than 5 ppm.  
   
   
       75 . The oxycodone hydrochloride composition of  claim 71 , having a lower limit of 0.25 ppm 14-hydroxycodeinone.  
   
   
       76 . The oxycodone hydrochloride composition of  claim 71 , having a lower limit of 0.5 ppm 14-hydroxycodeinone.  
   
   
       77 . The oxycodone hydrochloride composition of  claim 71 , having a lower limit of 1 ppm 14-hydroxycodeinone.  
   
   
       78 . The oxycodone hydrochloride composition of  claim 71 , having a lower limit of 2 ppm 14-hydroxycodeinone.  
   
   
       79 . The oxycodone hydrochloride composition of  claim 71 , having a lower limit of 5 ppm 14-hydroxycodeinone.  
   
   
       80 . A packaged oxycodone hydrochloride composition comprising a pharmaceutically acceptable package containing at least 1 kg of an oxycodone hydrochloride composition having a 14-hydroxycodeinone level in an amount of less than 25 ppm.  
   
   
       81 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a 14-hydroxycodeinone level in an amount of less than 15 ppm.  
   
   
       82 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a 14-hydroxycodeinone level in an amount of less than 10 ppm.  
   
   
       83 . The packaged oxycodone composition of  claim 80 , wherein the oxycodone hydrochloride composition has a 14-hydroxycodeinone level in an amount of less than 5 ppm.  
   
   
       84 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride is in an amount between about 10 kg and about 500 kg.  
   
   
       85 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride is in an amount between about 20 kg and about 100 kg.  
   
   
       86 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride is in an amount between about 20 kg and about 50 kg.  
   
   
       87 . The packaged oxycodone composition of  claim 80 , wherein the package is a corrugated box container.  
   
   
       88 . The packaged oxycodone composition of  claim 80 , wherein the package is a drum.  
   
   
       89 . The packaged oxycodone composition of  claim 80 , wherein the package is a flexible intermediate bulk container.  
   
   
       90 . The packaged oxycodone composition of  claim 80 , further comprising a liner between the package and the oxycodone composition.  
   
   
       91 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a lower limit of 0.25 ppm 14-hydroxycodeinone.  
   
   
       92 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a lower limit of 0.5 ppm 14-hydroxycodeinone.  
   
   
       93 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a lower limit of 1 ppm 14-hydroxycodeinone.  
   
   
       94 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a lower limit of 2 ppm 14-hydroxycodeinone.  
   
   
       95 . The packaged oxycodone hydrochloride composition of  claim 80 , wherein the oxycodone hydrochloride composition has a lower limit of 5 ppm 14-hydroxycodeinone.

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