Nuclear matrix proteins

Abstract

Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.

1 . An in vitro method for detecting prostate cancer in a human subject comprising contacting a specimen from the subject with an antibody that binds to BPC-1 protein and detecting binding of the antibody to BPC-1 protein, wherein the presence of BPC-1 protein in the specimen is indicative of prostate cancer.  
     
     
         2 . The method of  claim 1 , wherein the antibody is polyclonal.  
     
     
         3 . The method of  claim 1 , wherein the antibody is monoclonal.  
     
     
         4 . An in vitro method for detecting prostate cancer in a human subject comprising contacting a specimen from the subject with an antibody that binds to BPC-2 protein and detecting binding of the antibody to BPC-2 protein, wherein the presence of BPC-2 protein in the specimen is indicative of prostate cancer.  
     
     
         5 . The method of  claim 4 , wherein the antibody is polyclonal.  
     
     
         6 . The method of  claim 4 , wherein the antibody is monoclonal.  
     
     
         7 . An in vitro method for detecting prostate cancer in a human subject comprising contacting a specimen from the subject with an antibody that binds to BPC-3 protein and detecting binding of the antibody to BPC-3 protein, wherein the presence of BPC-3 protein in the specimen is indicative of prostate cancer.  
     
     
         8 . The method of  claim 7 , wherein the antibody is polyclonal.  
     
     
         9 . The method of  claim 7 , wherein the antibody is monoclonal.