US2006159782A1PendingUtilityA1

Material for promoting skin basement formation

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Assignee: SHISEIDO CO LTDPriority: Mar 27, 2000Filed: Dec 16, 2005Published: Jul 20, 2006
Est. expiryMar 27, 2020(expired)· nominal 20-yr term from priority
Inventors:Satoshi AmanoYukiko MatsunagaShinji Inomata
A61P 17/00A61L 27/22A61K 31/00A61K 8/64A61K 36/65A61K 45/06A61K 31/445A61Q 19/00A61K 2800/782A61L 2300/414A61L 27/60A61L 27/54A61K 36/82A61L 2300/434
55
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Claims

Abstract

A method for promoting skin basement membrane formation comprises administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.

Claims

exact text as granted — not AI-modified
1 . A method for promoting a skin basement membrane formation in a subject for which the skin basement membrane formation is necessary, comprising administering a matrix metalloproteinase inhibitor N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride to said subject.  
     
     
         2 . A method for promoting a skin basement membrane formation in a subject for which the skin basement membrane formation is necessary, comprising administering a matrix metalloproteinase inhibitor N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride and a matrix protein production promoting agent to said subject.  
     
     
         3 - 6 . (canceled)  
     
     
         7 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Thymus serpyllum  L.,  Valeriana fauriei  Briquet or other similar plants (Valerianaceae),  Diospyros kaki  Thunberg (Ebenaceae), and  Astragalus sinicus  Linne (Leguminosae).  
     
     
         8 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Crataegus cuneata  Siebold et Zuccarini (Rosaceae),  Paeonia suffruticosa  Andrews (Poeonia montan Sims) (Paconiaceae),  Thea sinensis  Linne var.  assamica  Pierre (Thcaccae), and  Eucalyptus globules  Labillardiere or its similar plants (Myrtaceae).  
     
     
         9 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Potentilla tormentilla  Schrk (Rosaceae),  Tilia corda : a Mill.,  Tilia platyphyllus  Scop., and  Tilia europaea  Linne (Tiliaceae).  
     
     
         10 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Betula alba  Linne (Betulaceze),  Origanum majorana  L.,  Uncaria gambir  Roxburgh (Rubiaceae), and  Juglans regia  Linne var.  sinensis  De Candolie or its similar plants (Juglandaceae).  
     
     
         11 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Sophora flavescens  Aiton (Leguminosae),  Sanguisorba officinalis  Linne (Rosaceae),  Hypericum perforatum  Linne or  Hypericum erectum  Thunberg (Guttiferae), and  Thea sinensis  Linne (Theaceae).  
     
     
         12 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Curcuma longa  L (Zingiberaceae), purified extracts of  Curcuma longa  L including  Symplocos racemosa  and  Cyperus rotundus, Cyperus scariosus, Gaultheria fragrantissima , and  Acacia formensia.    
     
     
         13 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Terminalia chebula, Ficus bengalensis, Cassia fistula  Linn,  Lyonia ovalifolia, Calophyllum inophyllum , and  Ficus religiosa.    
     
     
         14 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Thymus serpyllum  L.,  Valeriana fauriei  Briquet or other similar plants (Valerianaceae),  Diospyros kaki  Thunberg (Ebenaceae), and  Astragalus sinicus  Linne (Leguminosae).  
     
     
         15 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Crataegus cuneata  Siebold et Zuccarini (Rosaceae),  Paeonia suffruticosa  Andrews (Poeonia montan Sims) (Paconiaceae),  Thea sinensis  Linne var.  assamica  Pierre (Thcaccae), and  Eucalyptus globules  Labillardiere or its similar plants (Myrtaceae).  
     
     
         16 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Potentilla tormentilla  Schrk (Rosaceae),  Tilia corda : a Mill.,  Tilia platyphyllus  Scop., and  Tilia europaea  Linne (Tiliaceae).  
     
     
         17 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Betula alba  Linne (Betulaceze),  Origanum majorana  L.,  Uncaria gambir  Roxburgh (Rubiaceae), and  Juglans regia  Linne var.  sinensis  De Candolie or its similar plants (Juglandaceae).  
     
     
         18 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Sophora flavescens  Aiton (Leguminosae),  Sanguisorba officinalis  Linne (Rosaceae),  Hypericum perforatum  Linne or  Hypericum erectum  Thunberg (Guttiferae), and  Thea sinensis  Linne (Theaceae).  
     
     
         19 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Curcuma longa  L (Zingiberaceae), purified extracts of  Curcuma longa  L including  Symplocos racemosa  and  Cyperus rotundus, Cyperus scariosus, Gaultheria fragrantissima , and  Acacia formensia.    
     
     
         20 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Terminalia chebula, Ficus bengalensis, Cassia fistula  Linn,  Lyonia ovalifolia, Calophyllum inophyllum  and  Ficus religiosa.    
     
     
         21 . The method for promoting a skin basement formation in accordance with  claim 1 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Symplocos racemosa , a purified extract of  Curcuma longa  L.  
     
     
         22 . The method for promoting a skin basement formation in accordance with  claim 2 , further comprising mixing said matrix metalloproteinase inhibitor with a matrix metalloproteinase inhibitor selected from the group consisting of  Symplocos racemosa , a purified extract of  Curcuma longa  L.  
     
     
         23 . The method for promoting skin basement formation in accordance with  claim 2 , wherein said matrix protein production promoting agent is selected from the group consisting of one or more of soybean lysolecithin transforming growth factor α (TGFa), and transforming growth factor β1 (TGFb1).

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