Bioresorbable sealants for porous vascular grafts

Abstract

A bioresorbable sealant composition useful for impregnating implantable soft-tissue prostheses includes at least two polysaccharides in combination to form a hydrogel or sol-gel. The sealant compositions may optionally include a bioactive agent and/or be cross-linked subsequent to application of these compositions to the substrate surface.

1 . A device comprising: 
 an implantable soft tissue prosthesis and    a hydrogel comprising a combination of at least two different polysaccharides.    
   
   
       2 . The device of  claim 1 , wherein said prosthesis is porous.  
   
   
       3 . The device of  claim 1 , wherein said hydrogel is impregnated on a surface of said prosthesis.  
   
   
       4 . The device of  claim 1 , wherein said prosthesis is tubular having an inner surface and an outer surface.  
   
   
       5 . The device of  claim 4 , wherein said hydrogel is impregnated on said inner surface of said prosthesis.  
   
   
       6 . The device of  claim 1 , wherein said polysaccharides are selected from the group consisting of algin, carboxymethyl cellulose, carrageenan, furcellaran, agarose, guar, locust bean gum, gum arabic, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyalkylmethyl cellulose, pectin, partially de-acetylated chitosan, starch, starch derivatives, amylase, amylopectin, hyaluronic acid and its derivatives, heparin, xanthan, and combinations thereof.  
   
   
       7 . The device of  claim 1 , wherein said combination of polysaccharides is selected from the group consisting of alginic acid/pectin, alginic acid/chitosan, carrageenan type I/locust bean gum, carrageenan type I/pectin, carrageenan type II/locust bean gum, carrageenan type II/pectin, carrageenan type II/guar gum, carrageenan type IV/locust bean gum, locust bean gum/xanthan, guar gum/locust bean gum, guar gum/xantham, chitosan/heparin and agar/guar gum.  
   
   
       8 . The device of  claim 1 , wherein said hydrogel further comprises an anticoagulant.  
   
   
       9 . The device of  claim 8 , wherein said anticoagulant is selected from the group consisting of heparin, prostaglandin, urokinase, streptokinase, sulfated polysaccharide, albumin, and combinations thereof.  
   
   
       10 . The device of  claim 1 , wherein said prosthesis is impregnated with said hydrogel by a method selected from the group consisting of submersion and injection.  
   
   
       11 . The device of  claim 1 , wherein said hydrogel further comprises an ion selected from the group consisting of K + , Ca 2+ , Mg 2+ and combinations thereof.  
   
   
       12 . The device of  claim 1 , wherein said prosthesis comprises a porous material comprising a synthetic or natural polymer.  
   
   
       13 . The device of  claim 1 , wherein said prosthesis comprises a porous material selected from the group consisting of polyester, expanded poly(tetrafluoroethylene), nylon, polypropylene, polyurethane, polyacrylonitrile, and combinations thereof.  
   
   
       14 . The device of  claim 8 , wherein said hydrogel provides controlled release of said anticoagulant.