Methods and related compositions for the non-surgical removal of fat

Abstract

Compositions and methods useful in the non-surgical removal of localized fat deposits in patients in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion agents and pharmaceutically acceptable excipients but do not contain phosphotidylcholine. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.

1 . A medical composition for the non-surgical removal of localized fat deposits in a patient consisting of a fat solubilizing effective amount of at least one bile acid or salt thereof and optionally at least one excipient wherein said medical composition does not include phosphatidylcholine.  
     
     
         2 . The medical composition of  claim 1  wherein said at least one bile salt is selected from the group consisting of deoxycholic, chenodeoxycholic, 7-alpha-dehydroxylate, chenodeoxycholic, lithocholic, dihydroxy- and trihydroxy-bile salts.  
     
     
         3 . The medical composition of  claim 2  wherein said at least one bile salt is sodium deoxycholate.  
     
     
         4 . The medical composition of  claim 1  wherein said at least one excipient is benzyl alcohol, water or a combination thereof.  
     
     
         5 . A method for the non-surgical removal of localized fat deposits in a patient having localized fat accumulation comprising administering a fat solubilizing effective amount of a medical composition consisting of at least one bile acid or salt thereof and optionally at least one excipient, wherein said medical composition does not include phosphatidylcholine.  
     
     
         6 . The method of  claim 5  wherein said administering step is subcutaneous injection.  
     
     
         7 . The method of  claim 5  wherein said at least one bile salt is selected from the group consisting of deoxycholic, chenodeoxycholic, 7-alpha-dehydroxylate, chenodeoxycholic, lithocholic, dihydroxy- and trihydroxy-bile salts.  
     
     
         8 . The medical composition of  claim 7  wherein said at least one bile salt is sodium deoxycholate.  
     
     
         9 . The method of  claim 5  wherein said at least one excipient is benzyl alcohol, water or a combination thereof.  
     
     
         10 . The method of  claim 5  wherein said localized fat accumulation is selected from the group consisting of lower eyelid fat herniation, hyperlipidemia on the body, infraorbital fat herniation, lipodystrophy on the body, and fat deposits on the thighs, abdomen, upper back, chin and arms.  
     
     
         11 . A non-liposuction method for the non-surgical removal of localized fat deposits in a patient comprising the non-surgical administration of a medical composition consisting of at least one bile acid or salt thereof, and optionally at least one pharmaceutically acceptable excipient-wherein said medical composition does not include phosphatidylcholine.  
     
     
         12 . A method for non-surgical removal of a localized fat deposit in a patient comprising: administering to the localized fat deposit a composition consisting of a fat-solubilizing effective amount of deoxycholic acid or salt thereof and an excipient.  
     
     
         13 . The method of  claim 12  wherein said salt is sodium deoxycholate.  
     
     
         14 . The method of  claim 12  wherein said composition consists of 5% weight per volume deoxycholic acid or salt thereof.  
     
     
         15 . The method of  claim 12  wherein said composition consists of less than 1% weight per volume deoxycholic acid or salt thereof.  
     
     
         16 . The method of  claim 12  wherein said composition does not include phosphatidylcholine.  
     
     
         17 . The method of  claim 12  wherein said excipient is benzyl alcohol.  
     
     
         18 . The method of  claim 12  wherein said excipient is benzyl alcohol, water or a combination thereof.  
     
     
         19 . The method of  claim 12  wherein said administering step is subcutaneous injection.  
     
     
         20 . The method of  claim 12  wherein said administering step includes multiple treatments.  
     
     
         21 . The method of  claim 12  wherein said administering step is weekly.  
     
     
         22 . The method of  claim 12  wherein said localized fat deposit is selected from the group consisting of lower eyelid fat herniation, hyperlipidemia on the body, infraorbital fat herniation, lipodystrophy on the body, and fat deposits on the thighs, abdomen, upper back, chin and arms.  
     
     
         23 . A container comprising a 1 mL medical composition consisting of a fat-solubilizing effective amount of deoxycholic acid or salt thereof and an excipient.  
     
     
         24 . The container of  claim 23  wherein said salt is sodium deoxycholate.  
     
     
         25 . The container of  claim 23  wherein said composition consists of 5% weight per volume deoxycholic acid or salt thereof.  
     
     
         26 . The container of  claim 23  wherein said composition consists of 0.025 g deoxycholic acid or salt thereof.  
     
     
         27 . The container of  claim 23  wherein said excipient is water, benzyl alcohol or a combination thereof.  
     
     
         28 . The container of  claim 23  wherein said container is a syringe.