Systems and methods for treating a thrombus in a blood vessel

Abstract

Systems and methods for treating an occluding thrombus in a blood vessel of a patient. Ferrofluids having magnetic particles dispersed therein are introduced locally via a catheter, a micro-catheter, or intravenously, to the bloodstream of a patient. The ferrofluids are magnetically manipulated or moved throughout the blood vessels of the patient by an external magnetic field generator until the intended occluding thrombus is broken up and removed. The external magnetic field generator, which can be stationary or portable, creates a vortex, high velocity jets, or other motion, within the ferrofluids, by rotating or moving at least one magnet relative to the patient. The at least one magnet is provided in the magnetic field generator. The vortex, high velocity jets, or other motion of the ferrofluids are used to break-up and remove the occluding thrombus. Drugs or abrasive particles, or both, may be incorporated with the ferrofluids and delivered to the bloodstream with the ferrofluids to help break-up and remove the occluding thrombus as well. Upon removal of the thrombus, magnetic components of the ferrofluids may remain in the patient or may be magnetically recaptured and removed from the bloodstream.

1 . A system for treating an occluding thrombus in a blood vessel, the system comprising: 
 magnetically manipulable ferrofluids disposed within the blood vessel; and    a magnetic field generator, the ferrofluids being manipulated to remove the occluding thrombus from the blood vessel according to a magnetic field generated by the magnetic field generator.    
   
   
       2 . The system of  claim 1 , wherein the ferrofluids further comprises magnetic particles dispersed in a carrier fluid within the ferrofluids.  
   
   
       3 . The system of  claim 2 , wherein the carrier fluid is one of a water-based, a water-alcohol-based, or a hydrocarbon-based carrier fluid.  
   
   
       4 . The system of  claim 3 , wherein the carrier fluid is hydrophilic.  
   
   
       5 . The system of  claim 3 , wherein the carrier fluid is hydrophobic.  
   
   
       6 . The system of  claim 3 , wherein the ferrofluids further comprises abrasive particles mixed into the ferrofluids, the abrasive particles displaceable to a surface of the ferrofluids when exposed to a magnetic field.  
   
   
       7 . The system of  claim 4 , wherein the ferrofluids further comprise hydrophobic abrasive particles mixed into the ferrofluids, the hydrophobic abrasive particles displaceable to a surface of the ferrofluids when subject to the hydrophilic carrier fluid.  
   
   
       8 . The system of  claim 5 , wherein the ferrofluids further comprise hydrophilic abrasive particles mixed into the ferrofluids, the hydrophilic abrasive particles displaceable to a surface of the ferrofluids when subject to the hydrophobic carrier fluid.  
   
   
       9 . The system of  claim 3 , wherein the ferrofluids further comprise a thrombolytic drug.  
   
   
       10 . The system of  claim 9 , wherein the thrombolytic drug is bonded to one of the magnetic particles or the abrasive particles, is mixed into the carrier fluids, or is added to the ferrofluids by carrier particles to deliver the thrombolytic drug throughout the ferrofluids.  
   
   
       11 . The system of  claim 2 , wherein the ferrofluids further comprise a combination of abrasive particles and a thrombolytic drug carried with the ferrofluids.  
   
   
       12 . The system of  claim 1 , further comprising: 
 a catheter or micro-catheter for delivering the ferrofluids directly to a site of the occluding thrombus within the bloodstream.    
   
   
       13 . The system of  claim 12 , further comprising at least one sensor on or near a tip of the catheter or micro-catheter for determining the activity of the ferrofluids at the thrombus site.  
   
   
       14 . The system of  claim 12 , further comprising: 
 a guide-wire having a magnetic tip.    
   
   
       15 . The system of  claim 14 , further comprising; 
 at least one sensor on the tip of one of the catheter, the micro-catheter, or the guide-wire for determining the activity of the ferrofluids at the site of the occluding thrombus.    
   
   
       16 . The system of  claim 15 , wherein one of the at least one sensor is a deflection sensor to determine the amount of deflection of the guide-wire tip as an indication of the activity of the ferrofluids at the site of the occluding thrombus.  
   
   
       17 . The system of  claim 16 , wherein the at least one sensor further comprises a temperature or pressure sensor.  
   
   
       18 . The system of  claim 17 , wherein a strength, geometry or gradient of the magnetic field within the blood vessel is determined based on the data sensed from the at least one sensor.  
   
   
       19 . The system of  claim 1 , wherein the magnetic field generator further comprises: 
 a tubular member having a first end and a second end;    a collar positionable along a circumference of the tubular member between the first end and the second end of the tubular member;    at least one magnet provided with the collar;    a movable table movably mounted to a base, the movable table oriented to hold a human patient and movable into and out of the tubular member with the patient aboard said table; and    means for powering the movable table and the collar.    
   
   
       20 . The system of  claim 1 , wherein the magnetic field generator further comprises: 
 a tubular member having a first end and a second end;    a collar positionable along a circumference of the tubular member between the first end and the second end of the tubular member;    at least one magnet provided with the collar; and    means for powering the collar, wherein only a body part of a patient is received within the tubular member.    
   
   
       21 . The system of  claim 19 , wherein the collar is rotatable or movable.  
   
   
       22 . The system of  claim 20 , wherein the collar is rotatable or movable.  
   
   
       23 . The system of  claim 19 , wherein the at least one magnet is a permanent magnet.  
   
   
       24 . The system of  claim 19 , wherein the at least one magnet is an electromagnet.  
   
   
       25 . The system of  claim 20 , wherein the at least one magnet is a permanent magnet.  
   
   
       26 . The system of  claim 20 , wherein the at least one magnet is an electromagnet.  
   
   
       27 . The system of  claim 1 , further comprising means for intravenously delivering the ferrofluids to the bloodstream.  
   
   
       28 . The system of  claim 27 , wherein the ferrofluids are concentrated to a site of the occluding thrombus prior to the removal of the occluding thrombus by the ferrofluids.  
   
   
       29 . The system of  claim 1 , wherein the ferrofluids form a vortex, high-velocity jets or other motion for breaking-up the occluding thrombus upon manipulation by the magnetic field.  
   
   
       30 . The system of  claim 14 , wherein the guide-wire with the magnetic tip further comprises a magnetic re-capture device for re-capturing and directing magnetic components within the ferrofluids through the catheter or micro-catheter to remove the magnetic components of the ferrofluids from the blood vessel.  
   
   
       31 . A method for treating an occluding thrombus in a blood vessel, the method comprising: 
 delivering ferrofluids having magnetic particles disposed therein to an occluding thrombus within a blood vessel; and    magnetically manipulating the ferrofluids to remove the thrombus.    
   
   
       32 . The method of  claim 31 , wherein the magnetic particles are dispersed in a carrier fluid within the ferrofluids.  
   
   
       33 . The method of  claim 33 , wherein the carrier fluid is one of a water-based, a water-alcohol-based, or a hydrocarbon-based carrier fluid.  
   
   
       34 . The method of  claim 32 , wherein the carrier fluid is hydrophilic.  
   
   
       35 . The method of  claim 32 , wherein the carrier fluid is hydrophobic.  
   
   
       36 . The method of  claim 32 , further comprising: 
 impregnating the ferrofluids with abrasive particles, the ferrofluids and abrasive particles combining to break-up and remove the occluding thrombus by the magnetic manipulation of the ferrofluids.    
   
   
       37 . The method of  claim 36 , wherein the abrasive particles are displaced to a surface of the ferrofluids to help break-up and remove the occluding thrombus upon magnetic manipulation of the ferrofluids.  
   
   
       38 . The method of  claim 34 , wherein the abrasive particles are hydrophobic and are displaced to a surface of the ferrofluids by the hydrophilic carrier fluid of the magnetic particles, the displaced abrasive particles and ferrofluids combining to remove the occluding thrombus.  
   
   
       39 . The method of  claim 35 , wherein the abrasive particles are hydrophilic and are displaced to a surface of the ferrofluids by the hydrophobic carrier fluid of the magnetic particles, the displaced abrasive particles and ferrofluids combining to remove the occluding thrombus.  
   
   
       40 . The method of  claim 36 , further comprising: 
 mixing a thrombolytic drug with the ferrofluids, the ferrofluids and thrombolytic drug combining to break-up and remove the occluding thrombus.    
   
   
       41 . The method of  claim 40 , wherein the thrombolytic drug is bonded to one of the magnetic particles or the abrasive particles to mix with the ferrofluids.  
   
   
       42 . The method of  claim 40 , wherein the thrombolytic drug is mixed with the carrier fluid of the magnetic particles or is added by carrier particles to mix with the ferrofluids.  
   
   
       43 . The method of  claim 31 , further comprising: 
 impregnating the ferrofluids with a combination of the magnetic particles, the abrasive particles and a thrombolytic drug, the ferrofluids, magnetic particles, abrasive particles and thrombolytic drug combining to break-up and remove the occluding thrombus upon magnetic manipulation thereof.    
   
   
       44 . The method of  claim 31 , further comprising: 
 creating a vortex, high velocity jets or other motion with the ferrofluids by the magnetic manipulation of the ferrofluids, the vortex, high velocity jets or other motion of the ferrofluids aiding removal of the occluding thrombus from the blood vessel.    
   
   
       45 . The method of  claim 44 , wherein the vortex, high velocity jets or other motion of the ferrofluids detaches the thrombus form the blood vessel and the detached thrombus is mechanically extracted therefrom the blood vessel.  
   
   
       46 . The method of  claim 44 , wherein the vortex, high velocity jets or other motion of the ferrofluids breaks-up and removes the thrombus from the blood vessel.  
   
   
       47 . The method of  claim 31 , wherein the ferrofluids are delivered directly to the occluding thrombus using a catheter or a micro-catheter.  
   
   
       48 . The method of  claim 31 , wherein the ferrofluids are delivered intravenously and then magnetically manipulated to concentrate at the occluding thrombus.  
   
   
       49 . The method of  claim 47 , further comprising: 
 magnetically manipulating the ferrofluids using an external magnetic field generator into which at least a portion of a patient is placed, the magnetic field generator having a collar and at least one magnet that generates a magnetic field, the collar and the at least one magnet being positioned to externally encircle a body part having the occluding thrombus located therein, whereby the collar and the at least one magnet creates the magnetic field that magnetically manipulates the ferrofluids to break-up and remove the occluding thrombus.    
   
   
       50 . The method of  claim 49 , wherein the magnetic field manipulates the ferrofluids by rotating or moving the collar and the at least one magnet.  
   
   
       51 . The method of  claim 50 , further comprising: 
 sensing the activity of the ferrofluids at the occluding thrombus using a guide-wire having a magnetic tip and at least one sensor in the tip thereof.    
   
   
       52 . The method of  claim 51 , determining the activity of the ferrofluids by sensing the amount of deflection of the magnetic guide-wire tip using the at least one sensor.  
   
   
       53 . The method of  claim 51 , further comprising: 
 determining the activity of the ferrofluids at the occluding thrombus by sensing one or more of pressure, temperature, magnetic field strength, and magnetic field gradient using the at least one sensor.    
   
   
       54 . The method of  claim 50 , further comprising sensing the activity of the ferrofluids at the occluding thrombus using at least one sensor at a tip of a catheter or a micro-catheter.  
   
   
       55 . The method of  claim 54  further comprising: 
 determining the activity of the ferrofluids at the occluding thrombus by sensing one or more of pressure, temperature, magnetic field strength, magnetic field gradient, or guide-wire tip deflection using the at least one sensor.    
   
   
       56 . The method of  claim 49 , wherein the magnetic field generator is a portable tubular member into which a body part having the occluding thrombus is placed to magnetically manipulate the ferrofluids.  
   
   
       57 . The method of  claim 48 , further comprising: 
 magnetically concentrating the ferrofluids at the occluding thrombus using an external magnetic field generator into which at least a portion of a patient is placed, the magnetic field generator having a collar and at least one magnet that generates a magnetic field, the collar and the at least one magnet being positioned to externally encircle a body part having the occluding thrombus located therein; and    magnetically manipulating the ferrofluids using the external magnetic field generator by rotating or moving the collar and the at least one magnet to create the magnetic field that manipulates the ferrofluids to break-up and remove the occluding thrombus.    
   
   
       58 . The method of  claim 49 , wherein the at least one magnet is a plurality of magnets independently operable to generate the magnetic field.  
   
   
       59 . The method of  claim 49 , wherein the magnetic field generator or a position of the patient is altered to alter a gradient, strength or geometry of the magnetic field.