3,5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Abstract

3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

1 . A method for treating a disease or disorder mediated by inhibition of kinase comprising administering to a patient in need thereof a compound or pharmaceutically acceptable salt or solvate selected from  
     
       
         
         
             
             
         
       
     
   
   
       2 . A method of treating mycotic infection, malignancies or cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, comprising administering effective amounts of a compound or a pharmaceutically acceptable salt or solvate according to  claim 1 .  
   
   
       3 . A method of selectively inhibiting CDK kinase activity by administering a compound or pharmaceutically acceptable salt or solvate according to  claim 1 .  
   
   
       4 . A pharmaceutical composition containing a compound or a pharmaceutically acceptable salt or solvate according to  claim 1.