US2006140952A1PendingUtilityA1

Tumour necrosis factor binding ligands

66
Individually held — no corporate assignee on recordPriority: Aug 7, 1989Filed: Feb 22, 2006Published: Jun 29, 2006
Est. expiryAug 7, 2009(expired)· nominal 20-yr term from priority
Inventors:Deborah RathjenRoger Aston
C07K 2317/24C07K 2317/73A61K 47/6813C07K 2317/21C07K 16/241C07K 2319/00C07K 2317/55A61K 38/00C07K 2317/76A61P 35/00C07K 2317/75A61K 47/68C07K 2317/622
66
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Claims

Abstract

Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40 (peptide 307) of mature human TNF-α. The antibodies and fragments thereof may be used to identify antibodies capable of binding in the region of mature human TNF-α of amino acid resides 22 - 40. Antibodies or fragments thereof which bind particular regions of mature human TNF-α are shown to elicit particular biological activities dependent upon the particular region wherein binding occurs.

Claims

exact text as granted — not AI-modified
1 . An isolated antibody or fragment thereof which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         2 . An isolated antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         3 . An antibody or fragment thereof according to  claim 1 , wherein the antibody is a monoclonal antibody.  
     
     
         4 . An antibody or fragment thereof according to  claim 1 , wherein the antibody is a chimeric antibody.  
     
     
         5 . An antibody or fragment thereof according to  claim 1 , wherein the antibody is a humanized antibody.  
     
     
         6 . An antibody or fragment thereof according to  claim 1 , wherein the antibody is a human antibody.  
     
     
         7 . An antibody or fragment thereof according to  claim 2 , wherein the antibody is a monoclonal antibody.  
     
     
         8 . An antibody or fragment thereof according to  claim 2 , wherein the antibody is a chimeric antibody.  
     
     
         9 . An antibody or fragment thereof according to  claim 2 , wherein the antibody is a humanized antibody.  
     
     
         10 . An antibody or fragment thereof according to  claim 2 , wherein the antibody is a human antibody.  
     
     
         11 . A composition comprising an isolated antibody or fragment thereof which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         12 . A composition according to  claim 11 , wherein the antibody is a monoclonal antibody.  
     
     
         13 . A composition according to  claim 11 , wherein the antibody is a chimeric antibody.  
     
     
         14 . A composition according to  claim 11 , wherein the antibody is a humanized antibody.  
     
     
         15 . A composition according to  claim 11 , wherein the antibody is a human antibody.  
     
     
         16 . A composition comprising an isolated antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         17 . A composition according to  claim 16 , wherein the antibody is a monoclonal antibody.  
     
     
         18 . A composition according to  claim 16 , wherein the antibody is a chimeric antibody.  
     
     
         19 . A composition according to  claim 16 , wherein the antibody is a humanized antibody.  
     
     
         20 . A composition according to  claim 16 , wherein the antibody is a human antibody.  
     
     
         21 . An isolated single chain antibody which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         22 . An isolated single chain antibody which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         23 . An antibody according to  claim 21 , wherein the antibody is a monoclonal antibody.  
     
     
         24 . An antibody according to  claim 21 , wherein the antibody is a chimeric antibody.  
     
     
         25 . An antibody according to  claim 21 , wherein the antibody is a humanized antibody.  
     
     
         26 . An antibody according to  claim 21 , wherein the antibody is a human antibody.  
     
     
         27 . An antibody according to  claim 22 , wherein the antibody is a monoclonal antibody.  
     
     
         28 . An antibody according to  claim 22 , wherein the antibody is a chimeric antibody.  
     
     
         29 . An antibody according to  claim 22 , wherein the antibody is a humanized antibody.  
     
     
         30 . An antibody according to  claim 22 , wherein the antibody is a human antibody.  
     
     
         31 . A composition comprising an isolated single chain antibody which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         32 . A composition according to  claim 31 , wherein the antibody is a monoclonal antibody.  
     
     
         33 . A composition according to  claim 31 , wherein the antibody is a chimeric antibody.  
     
     
         34 . A composition according to  claim 31 , wherein the antibody is a humanized antibody.  
     
     
         35 . A composition according to  claim 31 , wherein the antibody is a human antibody.  
     
     
         36 . A composition comprising an isolated single chain antibody which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         37 . A composition according to  claim 36 , wherein the antibody is a monoclonal antibody.  
     
     
         38 . A composition according to  claim 36 , wherein the antibody is a chimeric antibody.  
     
     
         39 . A composition according to  claim 36 , wherein the antibody is a humanized antibody.  
     
     
         40 . A composition according to  claim 36 , wherein the antibody is a human antibody.  
     
     
         41 . An isolated single domain antibody or fragment thereof which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         42 . An isolated single domain antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         43 . An antibody or fragment thereof according to  claim 41 , wherein the antibody is a monoclonal antibody.  
     
     
         44 . An antibody or fragment thereof according to  claim 41 , wherein the antibody is a chimeric antibody.  
     
     
         45 . An antibody or fragment thereof according to  claim 41 , wherein the antibody is a humanized antibody.  
     
     
         46 . An antibody or fragment thereof according to  claim 41 , wherein the antibody is a human antibody.  
     
     
         47 . An antibody or fragment thereof according to  claim 42 , wherein the antibody is a monoclonal antibody.  
     
     
         48 . An antibody or fragment thereof according to  claim 42 , wherein the antibody is a chimeric antibody.  
     
     
         49 . An antibody or fragment thereof according to  claim 42 , wherein the antibody is a humanized antibody.  
     
     
         50 . An antibody or fragment thereof according to  claim 42 , wherein the antibody is a human antibody.  
     
     
         51 . A composition comprising an isolated single domain antibody or fragment thereof which binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         52 . A composition according to  claim 51 , wherein the antibody is a monoclonal antibody.  
     
     
         53 . A composition according to  claim 51 , wherein the antibody is a chimeric antibody.  
     
     
         54 . A composition according to  claim 51 , wherein the antibody is a humanized antibody.  
     
     
         55 . A composition according to  claim 51 , wherein the antibody is a human antibody.  
     
     
         56 . A composition comprising an isolated single domain antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala 22 -Glu 23 -Gly 24 -Gln 25 -Leu 26 -Gln 27 -Trp 28 -Leu 29 -Asn 30 -Arg 31 -Arg 32 -Ala 33 -Asn 34 -Ala 35 -Leu 36 -Leu 37 -Ala 38 -Asn 39 -Gly 40  (peptide 307) of the mature human TNF-α amino acid sequence.  
     
     
         57 . A composition according to  claim 56 , wherein the antibody is a monoclonal antibody.  
     
     
         58 . A composition according to  claim 56 , wherein the antibody is a chimeric antibody.  
     
     
         59 . A composition according to  claim 56 , wherein the antibody is a humanized antibody.  
     
     
         60 . A composition according to  claim 56 , wherein the antibody is a human antibody.

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