Separate type medical material

Abstract

A separate type medical material containing a hyaluronic acid ester derivative, which satisfies the storage stability of a hyaluronic acid ester derivative and avoidance of irritation and pain at the time of injecting a therapeutic agent for joints, is provided. A separate type medical material comprising liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, kept separately from each other.

1 . A separate type medical material, characterized in that it comprises liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5, and liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, and the liquid (A) and the liquid (B) are kept separately from each other before administration and administered as mixed.  
   
   
       2 . The separate type medical material according to  claim 1 , wherein the hyaluronic acid ester derivative in the liquid (A) is self-crosslinking hyaluronic acid.  
   
   
       3 . The separate type medical material according to  claim 1  or  2 , wherein the aqueous solution containing a hyaluronic acid ester derivative as the liquid (A) has a concentration of the hyaluronic acid ester derivative of from 1 to 20 mass %.  
   
   
       4 . The separate type medical material according to  claim 1 ,  2  or  3 , wherein the liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8, is an aqueous solution having hyaluronic acid dissolved therein.  
   
   
       5 . The separate type medial material according to any one of  claims 1  to  4 , which further contains a medicine or a pharmaceutically acceptable lubricant.  
   
   
       6 . The separate type medical material according to  claim 5 , wherein the medicine or the pharmaceutically acceptable lubricant is dissolved or dispersed in the liquid (A) which is an aqueous solution containing a hyaluronic acid ester derivative and buffered to a pH of from 4.5 to 6.5.  
   
   
       7 . The separate type medical material according to  claim 5  or  6 , wherein the medicine or the pharmaceutically acceptable lubricant is dissolved or dispersed in the inside of the hyaluronic acid ester derivative in the liquid (A).  
   
   
       8 . The separate type medical material according to any one of  claims 5  to  7 , wherein the medicine or the pharmaceutically acceptable lubricant is dissolved or dispersed in the liquid (B) which is an aqueous solution having such a buffering power that when it is mixed with the liquid (A), the mixed liquid has a pH within a range of from 6.8 to 7.8.  
   
   
       9 . The separate type medical material according to any one of  claims 5  to  8 , wherein the pharmaceutically acceptable lubricant is a phospholipid.  
   
   
       10 . The separate type medical material according to any one of  claims 1  to  9 , which is a medical material for joint injection comprising the liquid (A) and the liquid (B) packed in a syringe separately from each other.  
   
   
       11 . A method of administering a medical material for arthropathy, which comprises mixing liquid (A) and liquid (B) constituting the separate type medical material as defined in any one of  claims 1  to  10  immediately before administration, and injecting the resulting mixed liquid to the joint of a patient for administration.